Characteristic | Univariate analysis (unmatching) | Multivariate analysis (unmatching) | ||||||
---|---|---|---|---|---|---|---|---|
OS | LCSS | OS | LCSS | |||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Surgical procedure | ||||||||
Lobectomy | Reference | Reference | Reference | Reference | ||||
Segmentectomy | 1.561 (1.292–1.885) | < 0.001 | 1.551 (1.198–2.009) | 0.001 | 1.447 (1.197–1.750) | < 0.001 | 1.436 (1.108–1.861) | 0.006 |
Age (years) | ||||||||
≤ 60 | Reference | Reference | Reference | Reference | ||||
61–70 | 1.599 (1.390–1.838) | < 0.001 | 1.371 (1.147–1.638) | 0.001 | 1.484 (1.290–1.708) | < 0.001 | 1.307 (1.093–1.564) | 0.003 |
71–80 | 2.314 (2.023–2.648) | < 0.001 | 1.780 (1.497–2.118) | < 0.001 | 2.189 (1.911–2.507) | < 0.001 | 1.722 (1.445–2.052) | < 0.001 |
≥ 81 | 3.870 (3.281–4.565) | < 0.001 | 2.469 (1.962–3.107) | < 0.001 | 3.674 (3.110–4.340) | < 0.001 | 2.406 (1.908–3.035) | < 0.001 |
Sex | ||||||||
Female | Reference | Reference | Reference | Reference | ||||
Male | 1.525 (1.398–1.664) | < 0.001 | 1.378 (1.223–1.553) | < 0.001 | 1.502 (1.370–1.647) | < 0.001 | 1.320 (1.165–1.496) | < 0.001 |
Race | ||||||||
White | 1.619 (1.322–1.982) | < 0.001 | 1.373 (1.060–1.779) | 0.016 | 1.544 (1.260–1.892) | < 0.001 | 1.302 (1.003–1.689) | 0.047 |
Black | 1.671 (1.300–2.149) | < 0.001 | 1.615 (1.171–2.228) | 0.003 | 1.697 (1.316–2.188) | < 0.001 | 1.563 (1.129–2.164) | 0.007 |
Others | Reference | Reference | Reference | Reference | ||||
Marital status | ||||||||
No | 0.790 (0.724–0.862) | < 0.001 | 0.087 (0.724–0.921) | 0.001 | 0.776 (0.708–0.851) | < 0.001 | 0.821 (0.724–0.932) | 0.002 |
Yes | Reference | Reference | Reference | Reference | ||||
Laterality | ||||||||
Left | Reference | Reference | ||||||
Right | 1.011 (0.926–1.105) | 0.801 | 1.010 (0.895–1.140) | 0.873 | ||||
Primary site | ||||||||
Upper | 1.118 (1.017–1.229) | 0.020 | 1.159 (1.017–1.321) | 0.027 | ||||
Middle | 1.061 (0.860–1.308) | 0.582 | 1.126 (0.849–1.495) | 0.410 | ||||
Lower | Reference | Reference | ||||||
Histopathology | ||||||||
ADC | 1.356 (1.221–1.505) | < 0.001 | 1.425 (1.237–1.641) | < 0.001 | 1.203 (1.082–1.337) | 0.001 | 1.241 (1.075–1.432) | 0.003 |
SCC | 1.870 (1.667–2.097) | < 0.001 | 1.649 (1.402–1.939) | < 0.001 | 1.300 (1.152–1.467) | < 0.001 | 1.112 (0.940–1.317) | 0.216 |
Others | Reference | Reference | Reference | Reference | ||||
Grade | ||||||||
I | Reference | Reference | Reference | Reference | ||||
II | 2.065 (1.803–2.365) | < 0.001 | 2.370 (1.942–2.891) | < 0.001 | 1.745 (1.517–2.008) | < 0.001 | 2.123 (1.731–2.604) | < 0.001 |
III–IV | 2.648 (2.307–3.040) | < 0.001 | 3.321 (2.718–4.057) | < 0.001 | 2.180 (1.887–2.520) | < 0.001 | 2.967 (2.410–3.652) | < 0.001 |