Characteristic | Univariate analysis (matching) | Multivariate analyses (matching) | ||||||
---|---|---|---|---|---|---|---|---|
OS | LCSS | OS | LCSS | |||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Surgical procedure | ||||||||
Lobectomy | Reference | Reference | ||||||
Segmentectomy | 0.914 (0.730–1.444) | 0.434 | 0.920 (0.677–1.249) | 0.593 | ||||
Age (years) | ||||||||
≤ 60 | Reference | Reference | Reference | Reference | ||||
61–70 | 2.231 (1.456–3.420) | < 0.001 | 2.016 (1.152–3.527) | 0.014 | 2.012 (1.310–3.089) | 0.001 | 1.804 (1.028–3.164) | 0.040 |
71–80 | 3.530 (2.345–5.314) | < 0.001 | 3.265 (1.918–5.558) | < 0.001 | 3.169 (2.101–4.780) | < 0.001 | 2.966 (1.738–5.062) | < 0.001 |
≥ 81 | 4.836 (3.073–7.610) | < 0.001 | 3.119 (1.670–5.827) | < 0.001 | 4.780 (3.030–7.540) | < 0.001 | 3.078 (1.643–5.765) | < 0.001 |
Sex | ||||||||
Female | Reference | Reference | Reference | Reference | ||||
Male | 1.419 (1.149–1.753) | 0.001 | 1.408 (1.056–1.876) | 0.020 | 1.212 (0.979–1.501) | 0.078 | 1.228 (0.918–1.642) | 0.166 |
Race | ||||||||
White | 1.116 (0.730–1.705) | 0.613 | 1.074 (0.610–1.891) | 0.804 | ||||
Black | 0.816 (0.460–1.445) | 0.485 | 0.854 (0.401–1.818) | 0.683 | ||||
Others | Reference | Reference | ||||||
Marital status | ||||||||
No | 0.892 (0.722–1.102) | 0.288 | 1.064 (0.795–1.424) | 0.677 | ||||
Yes | Reference | Reference | ||||||
Laterality | ||||||||
Left | Reference | Reference | ||||||
Right | 1.117 (0.905–1.379) | 0.301 | 1.191 (0.894–1.587) | 0.231 | ||||
Primary site | ||||||||
Upper | 1.221 (0.978–1.525) | 0.077 | 1.189 (0.880–1.607) | 0.259 | ||||
Middle | 1.076 (0.607–1.906) | 0.803 | 1.012 (0.464–2.204) | 0.976 | ||||
Lower | Reference | Reference | ||||||
Histopathology | ||||||||
ADC | 1.298 (1.012–1.663) | 0.040 | 1.589 (1.138–2.218) | 0.007 | 1.194 (0.927–1.537) | 0.169 | 1.456 (1.037–2.047) | 0.030 |
SCC | 1.619 (1.238–2.119) | < 0.001 | 1.502 (1.021–2.209) | 0.039 | 1.248 (0.944–1.650) | 0.120 | 1.166 (0.781–1.740) | 0.453 |
Others | Reference | Reference | Reference | Reference | ||||
Grade | ||||||||
I | Reference | Reference | Reference | Reference | ||||
II | 1.881 (1.325–2.670) | < 0.001 | 1.612 (1.023–2.538) | 0.039 | 1.749 (1.216–2.516) | 0.003 | 1.430 (0.894–2.289) | 0.136 |
III–IV | 2.567 (1.803–3.653) | < 0.001 | 2.218 (1.405–3.502) | 0.001 | 2.267 (1.570–3.274) | < 0.001 | 1.957 (1.216–3.147) | 0.006 |