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Table 4 Univariate and multivariate cox proportional hazard analysis of overall mortality

From: Does the “obesity paradox” exist after transcatheter aortic valve implantation?

Variable Univariate analysis Multivariate analysis
HR 95%CI p HR 95%CI p
BMI (categorical)
 Middle versus Low 1.662 0.365–6.985 0.438 1.124 0.866–1.974 0.500
 High versus Low 0.887 0.368–0.935 0.029 1.231 0.920–1.995 0.738
BMIa (kg/m2) 0.959 0.922–0.968 0.032    
Age (years) 3.119 1.192–5.106 0.043 1.168 0.993–1.867 0.323
Male 1.032 0.988–1.996 0.788 0.855 0.733–1.457 0.534
Diabetes mellitus 0.932 0.329–2.503 0.779 3.930 1.995–4.885 0.034
Chronic lung disease 1.986 0.392–2.831 0.409 1.306 0.156–1.887 0.460
CAD 1.988 0.959–2.887 0.569 1.004 0.566–1.661 0.660
Previous MI 0.925 0.780–2.944 0.099    
Previous CABG or valve surgery 0.317 0.102–0.980 0.328    
Previous stroke/TIA 0.878 0.884–1.488 0.587    
GFR (mL/min/m2) 0.898 0.877–1.219  < 0.001 3.006 1.876–3.301 0.046
Atrial fibrillation 1.318 1.259–2.916 0.04 1.558 0.885–2.432 0.120
Frailty 3.125 2.035–3.152  < 0.001 3.825 1.968–4.730 0.003
Ejection fraction 0.958 0.881–0.976 0.01 1.678 0.807–1.806 0.063
Aortic valve mean gradient (mm Hg) 1.798 1.195–1.989 0.004 1.806 1.606–1.965 0.122
Aortic valve area (cm2) 1.006 0.625–1.986 0.763    
Valve type: VitaFlow®/J-Valve 1.160 0.914–1.246 0.108 1.803 0.875–1.954 0.098
Alternative access: Transfemoral/Transapical 2.940 1.338–2.957  < 0.001 1.551 1.022–1.997 0.088
  1. Covariates included in the multivariate analysis: BMI categories, age, gender, diabetes mellitus, chronic lung disease, coronary artery disease, glomerular filtration rate, atrial fibrillation, frailty, ejection fraction, aortic valve mean gradient, valve type, and alternative access
  2. HR hazard ratio, CI confidence interval, BMI body mass index, CAD coronary artery disease, MI myocardial infarction, CABG coronary artery bypass graft, TIA transient ischemic attack, GFR glomerular filtration rate
  3. aBMI as linear variable; hazard ratio per 1 kg/m2 increment