Does the “obesity paradox” exist after transcatheter aortic valve implantation?

Table 4 Univariate and multivariate cox proportional hazard analysis of overall mortality

Variable	Univariate analysis			Multivariate analysis
Variable	HR	95%CI	p	HR	95%CI	p
BMI (categorical)
Middle versus Low	1.662	0.365–6.985	0.438	1.124	0.866–1.974	0.500
High versus Low	0.887	0.368–0.935	0.029	1.231	0.920–1.995	0.738
BMI^a (kg/m²)	0.959	0.922–0.968	0.032
Age (years)	3.119	1.192–5.106	0.043	1.168	0.993–1.867	0.323
Male	1.032	0.988–1.996	0.788	0.855	0.733–1.457	0.534
Diabetes mellitus	0.932	0.329–2.503	0.779	3.930	1.995–4.885	0.034
Chronic lung disease	1.986	0.392–2.831	0.409	1.306	0.156–1.887	0.460
CAD	1.988	0.959–2.887	0.569	1.004	0.566–1.661	0.660
Previous MI	0.925	0.780–2.944	0.099
Previous CABG or valve surgery	0.317	0.102–0.980	0.328
Previous stroke/TIA	0.878	0.884–1.488	0.587
GFR (mL/min/m²)	0.898	0.877–1.219	< 0.001	3.006	1.876–3.301	0.046
Atrial fibrillation	1.318	1.259–2.916	0.04	1.558	0.885–2.432	0.120
Frailty	3.125	2.035–3.152	< 0.001	3.825	1.968–4.730	0.003
Ejection fraction	0.958	0.881–0.976	0.01	1.678	0.807–1.806	0.063
Aortic valve mean gradient (mm Hg)	1.798	1.195–1.989	0.004	1.806	1.606–1.965	0.122
Aortic valve area (cm²)	1.006	0.625–1.986	0.763
Valve type: VitaFlow®/J-Valve	1.160	0.914–1.246	0.108	1.803	0.875–1.954	0.098
Alternative access: Transfemoral/Transapical	2.940	1.338–2.957	< 0.001	1.551	1.022–1.997	0.088

Covariates included in the multivariate analysis: BMI categories, age, gender, diabetes mellitus, chronic lung disease, coronary artery disease, glomerular filtration rate, atrial fibrillation, frailty, ejection fraction, aortic valve mean gradient, valve type, and alternative access
HR hazard ratio, CI confidence interval, BMI body mass index, CAD coronary artery disease, MI myocardial infarction, CABG coronary artery bypass graft, TIA transient ischemic attack, GFR glomerular filtration rate
^aBMI as linear variable; hazard ratio per 1 kg/m² increment

ISSN: 1749-8090