Fig. 1
From: New progress in diagnosis and treatment of pulmonary arterial hypertension
Current and emerging targets and therapies for pulmonary arterial hypertension. Arrows represent receptor stimulation, whereas dashed arrow show receptor blockade. Abbreviations: PGIS, prostaglandin I synthase; IP, prostaglandin I2; AC, adenylate cyclase; cAMP, cyclic AMP; cGMP, cyclic GMP; eNOS, endothelial nitric oxide synthase; sGC, soluble guanylate cyclase; PDE-5, phosphodiesterase type 5; ECE-1, endothelin converting enzyme 1; ETA, endothelin receptor type A; ETB, endothelin receptor type B; ERA, endothelin receptor antagonists