Table 4 Univariable and multivariable cox regression analysis for postoperative CKD
Univariable | Multivariable | |||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age (y) | 1.024 (0.996–1.052) | 0.088 | 1.020 (0.993–1.049) | 0.153 |
BMI (kg/m2) | 0.934 (0.860–1.014) | 0.105 | ||
Male/female | 1.527 (0.839–2.779) | 0.166 | ||
Hypertension (N, %) | 1.962 (0.974–3.954) | 0.059 | 1.772 (0.856–3.666) | 0.123 |
Diabetes (N, %) | 1.885 (0.799–4.447) | 0.148 | ||
CHD (N, %) | 1.778 (0.795–3.975) | 1.161 | ||
Smoking history (N, %) | 1.075 (0.602–1.920) | 0.808 | ||
LVEF, % | 0.983 (0.934–1.034) | 0.499 | ||
Previous heart surgery (N, %) | 0.648 (0.157–2.672) | 0.548 | ||
Urgent surgery (N, %) | 1.065 (0.528–2.145) | 0.861 | ||
Renal arteries arising from the false lumen (N, %) | 1.033 (0.574–1.857) | 0.915 | ||
Main surgical procedure | ||||
Total arch replacement (N, %) | 0.934 (0.484–1.805) | 0.840 | ||
Total arch replacement and FET (N, %) | 1.845 (0.729–4.669) | 0.196 | ||
Hemiarch replacement (N, %) | 0.554 (0.248–1.239) | 0.151 | ||
Concomitant procedures | ||||
Bentall (N, %) | 1.108 (0.621–1.977) | 0.727 | ||
Ascending aorta replacement (N, %) | 0.800 (0.448–1.426) | 0.449 | ||
CABG (N, %) | 1.670 (0.405–6.889) | 0.478 | ||
Valve surgery (N, %) | 0.573 (0.205–1.598) | 0.287 | ||
Basic laboratory characteristics | ||||
AST (IU/L) | 1.001 (1.000–1.001) | 0.048 | 1.000 (0.999–1.000) | 0.428 |
ALT (IU/L) | 1.001 (1.000–1.001) | 0.117 | ||
Total bilirubin (μmol/L) | 0.994 (0.970–1.018) | 0.627 | ||
Direct bilirubin (μmol/L) | 0.963 (0.857–1.082) | 0.522 | ||
Albumin (g/L) | 1.004 (0.945–1.067) | 0.898 | ||
sCr (μmol/L) | 1.007 (1.003–1.011) | 0.001 | 1.010 (1.004–1.016) | 0.001 |
BUN (μmol/L) | 1.054 (0.954–1.164) | 0.299 | ||
CPB characteristics | ||||
CPB time (min) | 1.000 (0.995–1.004) | 0.934 | ||
Crossclamp time (min) | 0.996 (0.988–1.004) | 0.350 | ||
Circulatory arrest time (min) | 0.997 (0.967–1.028) | 0.847 | ||
Nadir Nasopharyngeal temperature (°C) | 0.967 (0.811–1.153) | 0.708 | ||
Nadir Rectal temperature (°C) | 0.999 (0.836–1.193) | 0.989 | ||
DHCA/MHCA | 1.270 (0.394–4.092) | 0.689 | ||
Surgery duration (h) | 0.980 (0.825–1.164) | 0.821 | ||
Received red blood cell (U) | 1.060 (0.981–1.145) | 0.140 | ||
Received plasma (ml) | 1.000 (0.999–1.000) | 0.810 | ||
Received cryoprecipitate (U) | 1.014 (0.977–1.053) | 0.458 | ||
Received blood platelet (U) | 1.017 (0.757–1.366) | 0.910 | ||
Received washed autologous blood (mL) | 1.000 (1.000–1.001) | 0.426 | ||
Blood loss (mL) | 1.000 (1.000–1.001) | 0.595 | ||
Sepsis (N, %) | 1.808 (0.561–5.829) | 0.321 | ||
Re-exploration for bleeding (N, %) | 2.001 (0.848–4.721) | 0.113 | ||
Postoperative laboratory characteristics | ||||
Peak total bilirubin (μmol/L) | 1.009 (1.001–1.016) | 0.018 | 1.006 (0.995–1.016) | 0.299 |
Peak AST (IU/L) | 1.000 (1.000–1.000) | 0.167 | ||
Peak ALT (IU/L) | 1.001 (1.000–1.001) | 0.007 | 1.001 (1.000–1.002) | 0.265 |
Non-AKI (N, %) | – | 0.001 | – | 0.018 |
AKI without HB (N, %) | 2.798 (1.129–6.932) | 0.026 | 2.887 (1.133–7.354) | 0.026 |
HB-AKI (N, %) | 5.406 (2.157–13.550) | < 0.001 | 4.490 (1.59–12.933) | 0.005 |