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Table 3 Univariate and multivariate analyses for factors associated with interval growth of small non-dominant tumors

From: Small nodules (≤ 6 mm in diameter) of multiple primary lung cancers: prevalence and management

Independent variables

Univariate predictors

Multivariate predictors

OR (95%CI)

P value

OR (95%CI)

P value

Age

0.43 (0.092, 2.024)

0.14

  

Sex

    

 Male

Reference

   

 Female

0.59 (0.21, 1.63)

0.41

  

Smoke

    

 None smoker

Reference

   

 Current smoker

3.57 (1.09, 11.6)

0.03

1.06 (0.45, 2.48)

0.89

 Former smoker

1.6 (0.53, 5.19)

0.37

  

CT density

    

 Pure GGN

Reference

   

 Part solid

4.18 (1.12, 14.94)

0.03

1.23 (1.08, 1.40)

0.029

 Solid

14.7 (4.74, 46.09)

< 0.001

3.50 (1.94, 6.30)

< 0.001

Nodule margin

    

 Regular

Reference

   

 Irregular

2.2 (0.37, 13)

0.19

  

 Spiculated

2.73 (0.76, 9.8)

0.06

1.08 (0.98, 1.19)

0.11

 Lobulated

0.93 (0.17, 4.8)

0.46

  

Nodule location

    

 Upper lobe

    

 Middle or lower lobe

0.32 (0.48, 1.26)

0.34

  

 History of cancer

5.5 (1.24, 24)

0.014

1.15 (0.81, 1.6)

0.072