Impact of frailty status on clinical and functional outcomes after concomitant valve replacement and bipolar radiofrequency ablation in patients aged 65 years and older

Table 3 Univariable and multivariable analyses of outcomes in full follow-up according to the frailty status

Outcomes	No. of events/total number of patients		Univariable		Multivariable
Outcomes	Frail	Non-frail	HR (95% CI)	P value	HR (95% CI)	P value
All-cause death^a	15/67	7/118	4.00 (1.69–9.49)	0.002	4.06 (1.33–12.38)	0.014
Cardiovascular death^b	7/67	3/118	3.26 (0.78–13.60)	0.110	2.85 (0.62–13.10)	0.180
Stroke or non-CNS embolism^c	7/60	7/116	4.25 (1.38–13.07)	0.011	2.21 (0.68–7.17)	0.186
All-cause hospitalization^d	16/60	18/116	2.47 (1.25–4.87)	0.009	2.24 (1.12–4.50)	0.023
Cardiovascular hospitalization^e	11/60	8/116	3.46 (1.38–8.67)	0.008	2.56 (0.92–7.11)	0.070

CNS, non-central nervous system
^a,b,c,d,eAdjusted for baseline covariates: age, gender, normal BMI, LVEF, NYHA (IV), hypoalbuminemia, smoking history, diabetes, hypertension, peripheral vascular disease, hypohepatia, COPD, Cancer, severe pulmonary hypertension, stroke/TIA, CAD, liver dysfunction, the number of valves requiring surgery, frailty

ISSN: 1749-8090