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Table 2 Descriptive statistics of demographics and confounders vs. pain treatment

From: The impact of a postoperative multimodal analgesia pathway on opioid use and outcomes after cardiothoracic surgery

Variable

Multimodal (MMA)

Opioid-based

p value a

N = 762

n = 383

n = 379

Age, year, median (IQR)

64 (57–71)

66 (59–72)

0.095

Sex, female, N (%)

115 (30%)

78 (20.6%)

0.0035

BMI, kg/m2

29.2 (26.1–33.3)

27.7 (25.0–31.7)

0.0006

Race/Ethnicity, N (Col.%)

   

 Caucasian

227 (59%)

260 (69%)

0.0017 b

 Other

156 (41%)

119 (31%)

  African American

124 (32%)

54 (14%)

 

  Hispanic

6 (1.6%)

10 (2.6%)

  Asian

16 (4.2%)

39 (10%)

  Other/unknown

10 (2.6%)

3 (0.8%)

 Caucasian and Asian

243 (63.5%)

299 (79%)

 

 Other

140 (36.5%)

80 (21%)

< 0.0001 b

STS risk-adjusted outcomes

   

 Prolonged postop ventilation

0.063 (0.038–0.10)

0.047 (0.030–0.077)

< 0.0001

 Operative Morbidity/mortality

0.101 (0.065–0.16)

0.076 (0.053–0.12)

< 0.0001

 Operative mortality

0.012 (0.0064–0.022)

0.0094 (0.0055–0.017)

0.0008

Surgery type, N (%)

  

< 0.0001

 CABG

261 (68%)

318 (84%)

 

 Valve

81 (21%)

36 (9.5%)

 

 Both

41 (11%)

25 (6.6%)

 

Psychotropicsc

  

0.048

 No

332 (87%)

308 (81%)

 

 Yes

51 (13%)

71 (19%)

 

# of adjuncts, N (Col. %)d

  

< 0.0001

 0

1 (0.3%)

1 (0.3%)

 

 1

13 (3.4%)

311 (82%)

 

 2

44 (11.5%)

60 (16%)

 

 3

296 (77%)

7 (1.8%)

 

 4

29 (7.6%)

0 (0.0%)

 
  1. BMI Body Mass Index, CABG Coronary Artery Bypass Grafting Surgery, STS Society of Thoracic Surgeons
  2. aMann–Whitney U Test, nonparametric equivalent to the t-test for continuous confounders. Fisher Exact Test for 2 × 2 tables or Chi-Square Test for n × 2 tables for categorical confounders
  3. bp = 0.0017 with Asians grouped with “Other”; p < 0.0001 with Asians grouped with Caucasian
  4. cPsychotropics: selective serotonin reuptake inhibitor, serotonin-norepinephrine reuptake inhibitor, tricyclic antidepressants, or benzodiazepines
  5. dAPAP, lidocaine, gabapentinoid or ketorolac. 0–1 adjuncts combined for analysis purposes