Table 3 Subgroup analysis
Subgroup | ORR | DCR | PFS | OS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of studies | OR and P | I2 (%) | No. of studies | OR and P | I2 (%) | No. of studies | HR and P | I2 (%) | No. of studies | HR and P | I2 (%) | |
Type of lung cancer | ||||||||||||
NSCLC | 6 | 2.73; 0.003 | 60.5 | 5 | 2.44; 0.004 | 25.1 | 5 | 0.4; 0.001 | 78.7 | 3 | 0.57; 0.064 | 77.9 |
Lung cancer | 2 | 2.95; 0.026 | 64.1 | 2 | 2.49; 0.001 | 0.0 | 2 | 0.48; 0.001 | 0.0 | 2 | 0.47; 0.001 | 0.0 |
Metastases | 0 | NA | NA | 0 | NA | NA | 0 | NA | NA | 1 | 0.27; 0.001 | 0.0 |
Stage of lung cancer | ||||||||||||
Advanced | 6 | 3.21; 0.001 | 65.4 | 5 | 2.54; 0.004 | 29.1 | 6 | 0.4; 0.001 | 73.8 | 4 | 0.55; 0.009 | 67.0 |
Other | 2 | 2.05; 0.001 | 0.0 | 2 | 2.43; 0.001 | 0.0 | 1 | 0.5; 0.001 | 0.0 | 2 | 0.4; 0.001 | 42.8 |
Previous treatment naive? | ||||||||||||
Yes | 4 | 2.51; 0.005 | 39.7 | 3 | 2.38; 0.027 | 45.0 | 5 | 0.4; 0.001 | 78.7 | 4 | 0.49; 0.008 | 74.4 |
No | 1 | 1.22; 0.653 | 0.0 | 1 | 1.37; 0.693 | 0.0 | 0 | NA | NA | 0 | NA | NA |
NA | 3 | 4.33; 0.005 | 73.7 | 3 | 2.7; 0.001 | 0.0 | 2 | 0.48; 0.001 | 0.0 | 2 | 0.47; 0.001 | 0.0 |
Randomized? | ||||||||||||
Yes | 5 | 3.29; 0.001 | 56.9 | 4 | 3.31; 0.001 | 0.0 | 2 | 0.43; 0.001 | 0.0 | 1 | 0.38; 0.001 | 0.0 |
No | 3 | 2.19; 0.028 | 58.1 | 3 | 2.05; 0.006 | 16.3 | 5 | 0.41; 0.001 | 79.2 | 5 | 0.52; 0.001 | 56.2 |
Type of ablation | ||||||||||||
RFA | 4 | 2.11; 0.045 | 68.1 | 4 | 1.96; 0.008 | 9.6 | 2 | 0.65; 0.166 | 82.0 | 3 | 0.51; 0.017 | 77.8 |
MWA | 4 | 3.76; 0.000 | 0.0 | 3 | 3.61; 0.001 | 0.0 | 5 | 0.34; 0.001 | 40.1 | 3 | 0.42; 0.001 | 0.0 |
Average age, year | ||||||||||||
≤ 60 | 5 | 2.81; 0.001 | 61.9 | 5 | 2.61; 0.001 | 0.0 | 4 | 0.45; 0.001 | 0.0 | 4 | 0.44; 0.001 | 0.0 |
> 60 | 3 | 2.7; 0.034 | 59.6 | 2 | 2.2; 0.211 | 69.3 | 3 | 0.4; 0.086 | 88.0 | 2 | 0.51; 0.246 | 85.9 |
Average follow up, month | ||||||||||||
> 24 | 2 | 2.98; 0.004 | 0.0 | 2 | 3.59; 0.001 | 0.0 | 4 | 0.51; 0.001 | 69.2 | 1 | 0.27; 0.001 | 0.0 |
≤ 24 | 2 | 1.75; 0.014 | 4.4 | 2 | 1.81; 0.048 | 25.6 | 0 | NA | NA | 4 | 0.53; 0.001 | 68.2 |
NA | 4 | 3.91; 0.004 | 67.7 | 3 | 3.14; 0.007 | 0.0 | 3 | 0.29; 0.001 | 55.8 | 1 | 0.49; 0.029 | 0.0 |
HR extracted from KM curve? | ||||||||||||
Yes | NA | NA | NA | NA | NA | NA | 4 | 0.51; 0.001 | 67.1 | 3 | 0.38; 0.001 | 0.0 |
No | NA | NA | NA | NA | NA | NA | 3 | 0.31; 0.001 | 68.7 | 3 | 0.61; 0.031 | 65.3 |