Table 2 Bottlenecks proteins with significant centrality values, based on betweenness
No | Gen name | Protein name | Betweenness score |
|---|---|---|---|
1 | APOA1 | Apolipoprotein A-I | 5451.761 |
2 | BGN | Biglycan | 2832.578 |
3 | SPP2 | Secreted phosphoprotein 24 | 1978.989 |
4 | APP | Amyloid-beta precursor protein | 1656.169 |
5 | ABCA1 | Phospholipid-transporting ATPase | 1425.333 |
6 | EAF1 | ELL-associated factor 1 | 1408.603 |
7 | APOB | Apolipoprotein B-100 | 1124.131 |
8 | MCTP2 | Multiple C2 and transmembrane domain-containing protein 2 | 1046.588 |
9 | TRIM41 | E3 ubiquitin-protein ligase TRIM41 | 1002.482 |
10 | BRAP | BRCA1-associated protein | 651.1595 |
11 | CDC37 | Hsp90 co-chaperone Cdc37 | 503.4186 |
12 | MIR760 | – | 501.196 |
13 | SDCBP | Syntenin-1 | 495.0561 |
14 | PCMT1 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase | 463.2281 |
15 | MIPOL1 | Mirror-image polydactyly gene 1 protein | 459.5198 |
16 | CLEC4G | C-type lectin domain family 4 member G | 453.8621 |
17 | MIR665 | – | 422.4701 |
18 | PLTP | Phospholipid transfer protein | 421.2035 |
19 | TGFB1 | Transforming growth factor beta-1 proprotein | 420.5315 |
20 | ACOXL | Isoform 3 of Acyl-coenzyme A oxidase-like protein | 415.5001 |