Table 1 Sapporo classification criteria [2]
Clinical criteria |
|---|
1. Vascular thrombosis |
≥1 Clinical episodes of arterial, venous, or small vessel thrombosis |
2. Pregency morbidity |
≥1 Unexplained deaths of a morphologically normal fetus ≥ 10th week of gestation |
≥1 Premature births of a morphologically normal neonate < 34th week of gestation due to: - eclampsia - severe pre-eclampsia - placental insufficiency |
≥3 Unexplained consecutive spontaneous abortions < 10th week of gestation (with exclusion of maternal anatomic, hormonal or chromosomal abnormalities) |
Laboratory criteria: on 2 or more occasions at least 12 weeks apart |
LA present in plasma |
aCL of IgG and/or IgM isotope in serum or plasma, present in medium or high titer (> 40 GPL or MPL, or > the 99th percentile) |
Anti-β2GP1 of IgG and/or IgM isotope in serum or plasma (in titer > the 99th percentile) |