Table 1 Patient characteristics and the distribution between surgery and chemotherapy

Age (years)

Median [range]

69 [37–89]

69 [37–89]

70 [51–82]

0.372

Sex

Male

42 (58.3)

30 (60)

12 (54.4)

0.796

Female

30 (41.7)

20 (40)

10 (45.5)

Extrapulmonary metastasectomy

No

58 (80.6)

42 (84)

16 (72.7)

0.335

Yes

14 (19.4)

8 (16)

6 (27.3)

Perioperative chemotherapy for CRC

No

44 (61.1)

27 (54)

17 (77.3)

0.072

Yes

28 (38.9)

23 (46)

5 (22.7)

CRC location

Colon

40 (60.6)

29 (64.4)

11 (52.4)

0.422

Rectum

26 (39.4)

16 (35.6)

10 (47.6)

CRC tumor size (mm)

Mean [range]

47 [18–110]

46 [18–110]

47 [20–100]

0.877

pT classification

T0

1 (1.5)

1 (2.2)

0 (0)

0.946

T1

3 (4.5)

2 (4.4)

1 (4.8)

T2

13 (19.7)

9 (20.0)

4 (19.0)

T3

30 (45.5)

19 (42.2)

11 (52.4)

T4

19 (28.8)

14 (31.1)

5 (23.8)

pN classification

N0

24 (36.4)

21 (46.7)

3 (14.3)

0.013

N1

25 (37.8)

16 (35.6)

9 (42.9)

N2

15 (22.7)

8 (17.8)

7 (33.3)

N3

2 (3.0)

0 (0)

2 (9.5)

CRC lymphatic invasion

Absent

10 (15.2)

9 (20)

1 (4.8)

0.15

Present

56 (84.8)

36 (80)

20 (95.2)

CRC vascular invasion

Absent

23 (34.8)

15 (33.3)

8 (38.1)

0.784

Present

43 (65.2)

30 (66.7)

13 (61.9)

Synchronicity of LM

No

36 (50)

28 (56)

8 (36.4)

0.2

Yes

36 (50)

22 (44)

14 (63.6)

DFI (months)

Mean [range]

10.3 [0-57.1]

11.7 [0-57.1]

6.8 [0-44.8]

0.179

LM size (mm)

Mean [range]

15 [2–55]

17 [2–55]

8 [2–12]

< 0.001

LM number

Mean [range]

2.8 [1–14]

1.6 [1–6]

5.4 [1–14]

< 0.001

Bilaterality of LM

Hemilateral

49 (68.1)

44 (88)

5 (22.7)

< 0.001

Bilateral

23 (31.9)

6 (12)

17 (77.3)

Pretreatment CEA > 5ng/ml

No

47 (65.3)

33 (66)

14 (63.6)

1

Yes

25 (34.7)

17 (34)

8 (36.4)