Giant endobronchial hamartoma resected by fiberoptic bronchoscopy electrosurgical snaring
© Mondello et al; licensee BioMed Central Ltd. 2011
Received: 15 April 2011
Accepted: 14 August 2011
Published: 14 August 2011
Less than 1% of lung neoplasms are represented by benign tumors. Among these, hamartomas are the most common with an incidence between 0.025% and 0.32%. In relation to the localization, hamartomas are divided into intraparenchymal and endobronchial.
Clinical manifestation of an endobronchial hamartoma (EH) results from tracheobronchial obstruction or bleeding. Usually, EH localizes in large diameter bronchus. Endoscopic removal is usually recommended. Bronchotomy or parenchimal resection through thoracotomy should be reserved only for cases where the hamatoma cannot be approached through endoscopy, or when irreversible lung functional impairment occurred after prolonged airflow obstruction. Generally, when endoscopic approach is used, this is through rigid bronchoscopy, laser photocoagulation or mechanical resection. Here we present a giant EH occasionally diagnosed and treated by fiberoptic bronchoscopy electrosurgical snaring.
Keywordstumor (lung) Pathology (lung) Hamartoma Lung cancer Imaging
Most tumors of the tracheobronchial tree are malignant [1, 2]. Benign lung tumors represent less than 1%, and among these, hamartomas, with an incidence between 0.025% and 0.32%, are the most common . In relation to the localization, hamartomas are divided into intraparenchymal, generally asymptomatic and with a radiological coin lesion appearance , and endobronchial, clinically manifesting as a result of tracheobronchial obstruction .
From a previous paper reviewing a total of 215 cases of hamartoma reported in the literature, the endobronchial location was found in only 1.4% of cases . In contrast, other studies found an incidence of endobronchial location in 10 and 20% of all pulmonary hamartomas [7, 8]. The endobronchial hamartomas (EH) usually localize in large diameter bronchus . Since these tumors are benign, endoscopic removal is usually recommended, reserving lung resection to cases of longstanding bronchial obstruction with infection and irreversible lung injury .
We report the case of a giant hamartoma of the left main bronchus, diagnosed and removed by fiberoptic bronchoscopy electrosurgical snaring.
The pulmonary hamartoma is a rare benign tumor, originating from the bronchial primitive mesenchymal tissue, which can differentiate into various mature mesenchymal components . In fact, the hamartoma, either intra-parenchymal or endobronchial, generally includes cartilage, bone, fat and muscle tissues . Usually, EH has a higher fat content than intraparenchymal hamarthoma . Generally, the cartilaginous component prevails over others, even though forms with predominantly fatty or bone components have been described as well .
EH is frequently asymptomatic, at least in the preocclusive early stage . When present, symptoms are secondary to tracheobronchial obstruction, resulting in recurrent pneumonias, and include fever, cough, hemoptysis, purulent sputum, dyspnea and pain [5, 6, 11, 12]. Sometimes, recurrent pneumonias secondary to bronchial obstruction may irreversibly damage the lung or part of it .
On CT scan, the EH appears as an endobronchial mass with or without signs of obstructive pneumonia or atelectasia . CT scan is of considerable diagnostic aid in cases of EH with high fat content . Stey et al. considered highly indicative the presence on CT scan of a mass at high fat density without contrast uptake .
At bronchoscopic examination, the EH appears as a polypoid or pedunculated neoplasm, well-circumscribed, with a smooth and yellowish surface, without signs of submucosal infiltration [1, 2]. Biopsies are necessary for the differential diagnosis from other benign neoplasms and from carcinoid . Histology would usually detect the coexistence of connective, epithelial, bone, muscle, fat and cartilage tissues, the latter usually in high prevalence [1, 9, 12].
The traditional treatment has been by thoracotomy with broncotomy or lung resection (12). However, since this is a benign neoplasm, endoscopic treatment is now widely recommended as the first line approach [1, 2, 4], also considering that malignant degeneration is extremely rare and the recurrence rate is low [2, 5, 6]. Generally, the endoscopic approach is through rigid bronchoscopy, laser photocoagulation or mechanical resection [15–18].
Laser treatment through rigid bronchoscopy is considered the gold standard treatment for symptomatic patients with bulky masses on radiological examination . However, in selected cases, the use of electrocautery through flexible bronchoscopy may prove just as simple and effective [4, 18]. Endoscopic electrosurgical snaring is widely used in gastroenterology , while its use in tracheobronchial endoscopy is rare. It is still not fully known the depth of electrocauterization . Possible complications may include bleeding, perforation and burning lesions on the tracheobronchial tree .
The traditional surgical treatment (thoracotomy and bronchotomy) is currently indicated only in cases where the EH cannot be approached through endoscopy, or when lung resection is indicated due to irreversible parenchymal damage from longstanding airway obstruction [9, 20].
The EH is a rare benign tumor that can cause bleeding or obstruction of the tracheobronchial tree.
For these reasons, treatment should be performed even in asymptomatic patients. The choice of treatment should consider the location and extent of the tumor. Surgical therapy, by bronchotomy or resection, should be reserved only for cases where the hamatoma cannot be approached through endoscopy, or when irreversible lung functional impairment occurred after prolonged airflow obstruction. In all other cases, in consideration of the benign nature of the tumor, the gold standard treatment is endoscopic laser resection. Fiberoptic bronchoscopy electrosurgical snaring may represent an alternative approach in selected cases.
Written informed consent was obtained from patients for publication of this report and accompanying images. A copy of the written consent is available for review by the Editor in chief of this journal.
- Stey CA, Vogt P, Russi EW: Endobronchial lipomatous amartoma. A rare cause of bronchial occlusion. Chest. 1998, 113: 254-255. 10.1378/chest.113.1.254.View ArticlePubMedGoogle Scholar
- Altin S, Dalar L, Karasulu L, Çetinkaya E, Timur S, Solmazer N: Resection of giant endobronchial hamartoma by electrocautery and cryotherapy via flexible bronchoscopy. Tüberküloz ve Toraks Dergisi. 2007, 55 (4): 390-394.Google Scholar
- Murray J, Kielkowski D, Leiman G: The prevalence and age distribution of peripheral pulmonary hamartoma in adult males: an autopsy based study. S Afr Med J. 1991, 79: 247-249.PubMedGoogle Scholar
- Kaya S, Karalezli A, Balkan E, Çakiroğlu E, Hasanoğlu HC: Endobronchial hamartoma removed by flexible fiberoptic bronchoscopy via electrocautery. Tüberküloz ve Toraks Dergisi. 2006, 54 (3): 273-276.Google Scholar
- Cosio GB, Villera V, Escave-Sustaeta J: Endobronchial hamartoma. Chest. 2002, 122: 202-205. 10.1378/chest.122.1.202.View ArticlePubMedGoogle Scholar
- Gjevre JA, Myers JL, Prakash USB: Pulmonary hamartoma. Mayo Clin Proc. 1996, 71: 14-20. 10.4065/71.1.14.View ArticlePubMedGoogle Scholar
- Sibala JL: Endobronchial hamartomas. Chest. 1972, 62: 631-634.View ArticlePubMedGoogle Scholar
- Tomashefski JF: Benign endobronchial mesenchymal tumors: their relationship to parenchymal pulmonary hamartomas. Am J Pathol. 1982, 6: 531-40. 10.1097/00000478-198209000-00005.View ArticleGoogle Scholar
- Cheu HW, Grishkin BA, Linville WK: Endobronchial hamartoma treated by bronchoscopy excision. South Med J. 1993, 86 (10): 1164-5. 10.1097/00007611-199310000-00018.View ArticlePubMedGoogle Scholar
- Gaerte SC, Meyer CA, Winer-Muram HT, Tarver RD, Conces DJ: Fat-containing lesions of the chest. RadioGraphycs. 2002, 22: 61-78.View ArticleGoogle Scholar
- Moran C, Suster S, Koss M: Endobronchial lipomas: a clinicopathologic study of four cases. Mod Pathol. 1994, 7: 212-14.PubMedGoogle Scholar
- Borro JM, Moya J, Botella A: Endobronchial hamartoma, report of seven cases. Scand J Thor Cardiovasc Surg. 1989, 23: 285-7.View ArticleGoogle Scholar
- Box K, Kerr KM, Jeffrey RR, Douglas JG: Endobronchial lipoma associated with lobar bronciectasis. Respir Med. 1991, 85: 71-72. 10.1016/S0954-6111(06)80214-3.View ArticlePubMedGoogle Scholar
- Ahn JM, Im JG, Seo JW, Han HS, Yoon HK, Kim WS, Yeon KM: Endobronchial hamartoma: CT findings in three patients. AJR. 1994, 163: 49-50.View ArticlePubMedGoogle Scholar
- Shah H, Garbe L, Nussbaum E, Dumon JF, Chiodera PL, Cavaliere S: Benign tumors of the tracheobronchial tree: endoscopic characteristics and rolke of laser resection. Chest. 1995, 107: 1744-51. 10.1378/chest.107.6.1744.View ArticlePubMedGoogle Scholar
- Birkholz SC, Galle J, Kanzow G, Kirrsten D: Bronchoscopic resection of an endobronchial hamartochondroma. Pneumologie. 2004, 58: 489-92. 10.1055/s-2004-818503.View ArticlePubMedGoogle Scholar
- Ortis-Saracho J, Picher J, Garcia-Rull S, Reboiras SD, Perez I: Endobronchial hamartoma resected by rigid bronchoscope. Eur J Cardiothorac Surg. 1993, 7: 445-6. 10.1016/1010-7940(93)90012-Z.View ArticleGoogle Scholar
- Horio H, Sakaguchi K, Ohta T: Endobronchial hamartoma removed by bronchoscopic electrosurgical snaring. Kyobu Geka. 2005, 58: 559-63.PubMedGoogle Scholar
- van Boxem TJ, Westerga J, Venmans BJ, Postmus PE, Sutedja TG: Tissue effects of bronchoscopic electrocautery: bronchoscopic appearance and histologic changes of bronchial wall after electrocautery. Chest. 2000, 117: 887-91. 10.1378/chest.117.3.887.View ArticlePubMedGoogle Scholar
- Na W, Shinn SH, Paik SS: Dumbbell shaped exophytic and endobronchial lipomatous hamartoma. Thorac Cardiovasc Surg. 2009, 57 (2): 122-4. 10.1055/s-2007-989350.View ArticlePubMedGoogle Scholar
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