Coronary Artery bypass grafting and/or valvular surgery in patients with previous pneumonectomy

  • Alexander Fragkidis1,

    Affiliated with

    • Alexander Dimitriou1 and

      Affiliated with

      • Dimitrios Dougenis1Email author

        Affiliated with

        Journal of Cardiothoracic Surgery20127:110

        DOI: 10.1186/1749-8090-7-110

        Received: 1 April 2012

        Accepted: 23 September 2012

        Published: 10 October 2012

        Abstract

        There is a lack of data regarding heart surgery on patients who have been previously pneumectomized. These patients pose unique challenges and surgical management may necessitate deviations from standard methods in the perioperative course. To summarize the available knowledge and to assess the optimal methods, we reviewed all reported patients with prior pneumonectomy who were subjected to coronary artery bypass grafting and/or valve surgery.

        In a Medline search from 1966 to May 2011 carefully undertaken, we identified 22 articles, including 29 patients who underwent 30 operations: CABG 70%, valvular surgery 23%, and combination 7%. Severe morbidity was 37% and 30-day mortality 13%.

        Although postoperative morbidity and mortality remain higher in previously pneumectomized patients undergoing coronary artery bypass grafting and valvular surgery, the gathered experience up to date suggests that a carefully planned surgical strategy, along with the use of advanced modern techniques may reduce morbidity and improve final outcome.

        Background

        Previous pneumonectomy is a rare comorbidity among patients undergoing open heart surgery for ischemic or valvular heart disease and poses unique intraoperative and postoperative challenges. Although several authors have proposed experience-based standards and considerations concerning surgical strategies for these patients, official guidelines have yet to be established. In this study, our aim was to review the current data and established suggestions and general principles in cardiac surgery on the pneumectomized patients.

        Methods

        We conducted a MEDLINE search from 1966 to May 2011 for available literature on patients with previous pneumonectomy who underwent open heart surgery for coronary artery bypass grafting (CABG) and/or valve repair or replacement, alone or in combination. The collected data was evaluated in detail and the site of operation, the type of cardiac procedure as well as the relative demographic data and the final outcome for each patient were individually presented.

        Results

        The results are summarized in Table 1. We identified 29 patients whose cases were reported in 22 articles [122]. The mean age of the patients was 67 years, ranging from 48 to 83 years; 72% of patients (n = 21) were male; 66% of patients (n = 19) had undergone left pneumonectomy; mean elapsed time between pneumonectomy and operation was 19 years, ranging from 9 months to 51 years.
        Table 1

        Summary of 29 Reported Patients In The Literature With Previous Pneumonectomy who Underwent CABG and/or Valve Replacement/Repair Surgery*

        Author/Year

        Patient No.

        Age/Gender/ Site/Elapsed time

        Preoperative Data

        Operation

        Postoperative Complications/Course

        Lecharpentier et al [1]/ 1988

        1

        66/M/Left/12 y

        DLCO, (78%); PaO2, 80 mmHg; PaCO2, 43 mmHg; pH, 7.35

        CABG: LIMA → LADA (median sternotomy, on-pump)

        Inotropic support, respiratory failure, pneumothorax/ Discharged on day 10

         

        2

        66/F/Right/36 y

        DLCO, (95%)

        Mitral valve replacement, tricuspid valve annuloplasty (median sternotomy, on-pump)

        Inotropic support, atrial fibrillation/ Died on day 12

        Medalion et al [2]/1994

        3

        70/F/Left/40 y

        FEV1, 0.95 L (45%); FVC, 1.3 L (52%)

        CABG: 3 SVGs, LIMA (median sternotomy, on-pump)

        None/Discharged on day 11

        Shibata et al [3]/1994

        4

        67/M/Left/13 y

        FEV1, (77%); FVC, (55%); room air PaO2, 92 mmHg; PaCO2, 45 mmHg

        CABG: 3 SVGs (median sternotomy, on-pump)

        None /Discharged on day 57

        Berrizbeitia et al [4]/1995

        5

        61/M/Right/42 y

        FEV1, 0.59 L (21%); FVC, 1.27 L (32%); DLCO, (48%); room air PaO2, 77 mmHg; PaCO2, 48 mmHg; pH, 7.40; TLC, 2.97 (49%); PAP, 25/14 mmHg

        CABG: 3 SVGs → LADA, OMB, PDA (median sternotomy, on-pump)

        None/Discharged on day 18

        Izzat et al [5]/1995

        6

        65/M/Right/10 y

        Not specified

        Mitral valve replacement (median sternotomy, on-pump)

        Postoperative hypotension;pneumothorax; mediastinitis; sepsis/Died on day 12

        Demirtas et al [6]/1995

        7

        63/M/Left/20 y

        FEV1, 1.09 L (36%); FVC, 1.36 L (36%); room air PaO2, 68 mmHg; PaCO2, 36 mmHg; PAP, 28/11 mmHg

        CABG: LIMA → LADA SVG → 1OMG (median sternotomy, on-pump)

        None /Discharged on day 7

        Soltanian et al [7]/1998

        8

        70/F/Left/19 y

        FEV1, 1.06 L; FVC, 1.58 L

        CABG: SVG → LADA (left thoracotomy, on-pump)

        Respiratory failure; pulmonary embolism; pneumonia /Diedon day 6

        Lippmann and Au [8]/2000

        9

        68/M/Left/15 y

        FEV1, 1.65 L (56%); FVC, 2.30 L (60%)

        CABG: 3 SVGs (median sternotomy, on-pump)

        Postoperative bleeding requiring re-exploration; respiratory failure; atrial fibrillation; hemothorax/ Discharged on day 48

         

        10

        73/M/Left/22 y

        FEV1, 1.65 L (53%); FVC, 2.40 L (58%)

        CABG:SVG, LIMA (median sternotomy, on-pump)

        None / Discharged on day 9

        Golbasi et al [9]/2001

        11

        58/M/Right/9 mo

        FEV1, 1.42 L (50%); FVC, 1.57 L (44%); room air PaO2, 76 mmHg; PaCO2, 38 mmHg; pH, 7.51; PAP, 35/18 mmHg

        CABG: 3 SVGs → LADA, 1OMB, PDA (median sternotomy, on-pump)

        Respiratory failure / Discharged on day 12

        Diab et al [10]/2001

        12

        64/M/Right/6 y

        PaO2, 68 mmHg; PaCO2, 46 mmHg; pH, 7.38

        CABG: SVG (median sternotomy, on-pump)

        Pneumothorax / Discharged on day 20

        El-Hamamsy et al [11]/2003

        13

        65/F/Right/51 y

        FEV1,0.86 L (36%); FVC, 1.37 L (44%)

        Mitral valve replacement, tricuspid valve annuloplasty (median sternotomy, on-pump)

        None / Discharged on day 6

         

        14

        71/F/Right/50 y

        FEV1, 0.60 L (28%); FVC, 0.75 L (27%)

        CABG: SVGs (median sternotomy, off-pump)

        None / Discharged on day 7

        Kumar et al [12]/2003

        15

        70/M/ Left/ 15 y

        FEV1, 1.74 L; FVC, 3.18 L; room air PaO2, 62 mmHg; PaCO2, 37 mmHg; KCO, (72%)

        CABG: LIMA → LADA SVG → PDA (median sternotomy, off-pump)

        None / Discharged on day 5

        Erdil et al [13]/2004

        16

        51/M/ Right/ 17 y

        FEV1, 1.5 L (45%); FVC, 1.9 L (43%); DLCO, (71%); PaO2, 72.6 mmHg; PaCO2, 38.7 mmHg; pH, 7.47

        CABG: RA → RCA RA(Y) → LADA, OMB (median sternotomy, on-pump)

        None / Discharged on day 10

        Shanker et al [14]/2005

        17

        80/M/ Left / 27 y

        FEV1, 1.0 L (46%); DLCO/VA, (53%); mean PAP, 54 mmHg

        Mitral valve repair, aortic valve replacement, CABG: SVG → LADA, diagonal branch (median sternotomy, on-pump)

        None / Discharged on day8

        Bernet et al [15]/ 2006

        18

        58/M/ Right /3 y

        FEV1, 1.41 L (59%); FVC, 2.22 L (59%)

        CABG: LIMA → LADA SVG → LCX, RCA (median sternotomy, on-pump)

        None / Discharged on day 7

        MH Us et al [16]/2006

        19

        74/M/ Left /15 y

        FEV1, 1.35 L (45%); FEV1/FVC, 0.65 (60%), PaO2, 64 mmHg; PaCO2, 45 mmHg; pH, 7.42

        Mitral valve replacement, subaortic membrane resection (median sternotomy, on-pump)

        None / Discharged on day 7

        MH Us et al [17]/2010

        20

        65/M/ Left /8 y

        FEV1, 1.30 L (45%); FEV1/FVC, 0.60 (50%); PaO2, 60 mmHg; PaCO2, 48 mmHg

        CABG: SVG → LADA, circumflex (left thoracotomy, off-pump)

        None / Discharged on day 5

        Stoller et al [18]/2007

        21

        54/F/ Left /3 y

        FEV1, 1.63 (61%); FVC, 2.03 (61%)

        CABG: 3 SVGs → RCA, LADA, LCX (emergent median sternotomy, on-pump)

        Respiratory failure; pneumonia / Discharged on day 26; admitted 8 y later with respiratory and congestive heart failure

         

        22

        48/M/ Left /18 y (before first surgery), 26 y (before second surgery)

        First surgery: PAP, 65/30 mmHg; CO, 6.7 L/min. No pulmonary function tests available due to emergency of situation

        Tricuspid and mitral valve repair (re-sternotomy, on-pump)

        Atrial fibrillation / Discharged on postoperative day 13

        Second surgery: FEV1, 1.36 L (37%); FVC, 1.94 (42%); FEV1/FVC, 0.71 (85%); RVSP, 52 mmHg

         

        23

        71/M/ Left /7 y

        FEV1, 1.17 L (33%); FVC, 1.86 L (40%); FEV1/FVC, 0.63 (83%); room air PaO2, 79 mmHg; PaCO2, 41 mmHg; pH, 7.46

        Mitral valve replacement, tricuspid valve annuloplasty (median sternotomy, on-pump)

        Hypotension and renal failure; atrial fibrillation / Survived (no further data)

         

        24

        74/F/ Left/37 y

        FEV1, 1.47 L (75%); FVC, 1.83 L (70%); FEV1/FVC, 0.81 (106%)

        CABG: 4 SVGs → LADA, lateral circumflex, high lateral circumflex, diagonal branch (left thoracotomy, on-pump)

        None / Discharged on day 6; experienced stroke on day 18; died on day 22

        Zhao et al [19]/2008

        25

        57/M/ Left /7 y

        FEV1, 2.24 L (62%); FVC, 3.21 L (70%)

        CABG: 2 SVGs → LADA, OMB, RCA (left thoracotomy, off-pump)

        None / Discharged on day 9

        Ghotkar et al [20]/2008

        26

        71/M/ Left /18 y

        FEV1, 1.1 L (42%); FVC, 1.8 L (53%); FEV1/FVC, 0.79

        CABG: SVG → LADA, PDA (median sternotomy, on-pump)

        Excessive bleeding requiring re-exploration; atelectasis / Discharged on day 17

         

        27

        77/F/ Right /13 mo

        FEV1, 0.7 L (64%); FVC, 0.9 L (63%); FEV1/FVC, 1.04

        Aortic valve replacement (median sternotomy, on-pump)

        None / Not specified

        Stamou et al [21]/2010

        28

        83/M/ Left /8 y

        FEV1, (48%); DLCO, (77%)

        Aortic valve replacement, CABG: SVGs (left thoracotomy, on-pump)

        None / Discharged on day 5

        Ushijima et al [22]/2011

        29

        82/M/ Left /20 y

        FEV1, 1.28 L (64%); FVC, 1.89 L (64%); PaO2, 85 mmHg; PaCO2, 43 mmHg; pH, 7.40

        CABG: LIMA, RA (Y) → LADA, posterolateral artery (left thoracotomy, off-pump)

        None / Not specified

        * DLCO = diffusing capacity of the lung for carbon monoxide; F = female; FEV1 = forced expiratory volume in one second; FVC = forced vital capacity; KCO = transfer factor; LADA = left anterior descending artery; LCX = left anterior circumflex artery; LIMA = left internal mammary artery; M = male; OMB = obtuse marginal branch; 1OMB = first obtuse marginal branch; PaO2 = arterial oxygen partial pressure; PaCO2 = arterial carbon monoxide partial pressure; PAP = pulmonary arterial pressure; PDA = posterior descending artery; RA = radial artery; RCA = right coronary artery; RVSP = right ventricular systolic pressure; SVG = saphenous vein graft; VA = alveolar volume; (Y) = y-graft. Percentiles in parentheses refer to percentiles of predicted values. Days mentioned in the table refer to postoperative days.

        All but one patient underwent one operation, apart from patient 22 who underwent two; therefore, 30 cardiac operations were performed on 29 patients. The most common operation performed was CABG alone (n = 21, 70%), followed by valvular surgery alone (n = 7, 23%) and combined CABG and valvular surgery (n = 2, 7%). Median sternotomy was the approach of choice in 80% of the cases (n = 24). Left thoracotomy was used in the rest 20% (n = 6), which involved only patients with previous left specifically pneumonectomy. Six (20%) underwent Off-pump CABG (OPCAG). In 3 of these operations left thoracotomy was the preferred approach.

        FEV1 percentiles of predicted values were reported preoperatively in 23 cases and the mean percentile was 49% of predicted, ranging from 21% to 77% of predicted. In addition, preoperative FVC percentiles of predicted values were provided in 19 cases and the mean percentile was 51% of predicted, ranging from 27% to 70% of predicted. Preoperative arterial blood oxygen levels were provided in 12 cases and mean value was 74 mmHg, ranging from 60 to 92 mmHg. For arterial blood carbon dioxide, whose preoperative levels were reported in 12 cases, mean levels were 42 mmHg, ranging from 36 to 48 mmHg. Of the 30 operations performed, 11 (37%) were followed by complications, the most common being respiratory failure (n = 5, 17%), atrial fibrillation (n = 4, 13% of operations) and pneumothorax (n = 3, 10%), while 30-day mortality rate was 13% (n = 4).

        Discussion

        The current review covers the database up to date regarding coronary revascularization and valvular procedures via open heart surgery in previously pneumonectomised patients. During our search we identified three articles [2, 10, 18] presenting a review of the subject. The first one by Medalion et al. [2] in 1994 was based on a worldwide survey of 118 members of the Society of Thoracic Surgeons, along with available data from the literature and one newly described patient. They presented collective data for 27 previously pneumonectomized patients who had undergone CABG and/or valve surgery. CABG was performed in 81% of cases, followed by mitral valve replacement in 19%. There were reported difficulties in exposing the circumflex marginal branches of 2 patients with left pneumonectomy. The most common postoperative complication was pneumothorax in 11% of patients, followed and postpericardiotomy syndrome in 4%, while the mortality rate was 7%.

        In the second article by Diab et al [10] in 2001, the authors searched the MEDLINE database to identify six previously pneumonectomized patients from the literature and added one newly described patient to their review. All seven patients had undergone CABG. Forty-three percent of patients developed postoperative complications, the most common of them being pneumothorax and respiratory failure requiring re-intubation (29%) and prolonged ventilation. Overall mortality was 14%.

        The third and most recent review was published by Stoller et al [18] in 2007. By searching the MEDLINE database from 1966 to 2006, they identified 15 patients with previous pneumonectomy who had undergone CABG and/or valve surgery, and also included 4 such patients from their institution’s Cardiovascular Information Registry. A total of 20 operations were performed in the 19 reviewed patients. CABG accounted for 75%, valve replacement or repair was performed in 20% and concomitant CABG and valve replacement/repair were performed in 5% of operations. Postoperative complications were reported in 50%, with the most common being respiratory failure and pneumothorax, in 25% and 10% of operations respectively. The 30-day mortality rate was 16%. Our current review includes the 15 patients reviewed by Stoller et al [18] (patients 1–5, 7–15 and 17), as well as the 4 newly described patients by Stoller et al [18] (patients 21–24). We extend our review by adding 10 more patients from the available up to date literature (patients 6, 16, 18–20 and 25–29) and believe, therefore, that all reported cases have been included and evaluated in this review.

        It is well known that previously pneumonectomised patients have substantially reduced pulmonary capacities [23]. Although there is not precise data, most pneumonectomies had been performed for malignancy. In the current series, mean preoperative FEV1 and FVC values were 49% and 51% of predicted values respectively. Thus, preoperative respiratory physiotherapy, as well as steroids, bronchodilators and antibiotics should be used to improve postoperative morbidity and mortality rates in this high-risk group [24, 25] We also believe that proper re-staging of the disease, in those pneumonectomised for lung carcinoma, should be undertaken preferably using a Positron Emission Tomography scan.

        Pneumonectomy also incurs marked anatomical changes in the thorax [26, 27]. This may necessitate deviations from standard protocols regarding open-heart surgery. For instance, in patients with previous left pneumonectomy, the heart and great vessels shift into the left chest and rotate [27]. This means that exposure of key sites for cardiopulmonary bypass cannulation, revascularization and valvular surgery may be easier via a left thoracotomy rather than a standard median sternotomy [7, 18, 19, 21, 22]. Stamou et al. [21] highlighted easy access to the aorta, the aortic root and the coronary arteries approaching the heart through a left thoracotomy in patients with previous left pneumonectomy. Nonetheless, since the degree of mediastinal shift varies greatly for each patient [26], alternative sites should be used if standard aortic cannulation is not possible and preoperative imaging tests, mainly chest CT scan, should be performed to assess best exposure of target sites. In our review, 6 patients with previous left pneumonectomy, underwent surgery via left thoracotomy, 5 underwent CABG alone (patients 8, 21, 24, 25 and 19) and 1 underwent combined CABG and aortic valve replacement (patient 28). Overall mortality rate for this subgroup of patients was 17%, n = 7.

        Another consideration in patients with previous pneumonectomy is the ability to establish cardiopulmonary bypass (CPB). Berrizbeitia et al [4] reported difficulty during cannulation of inferior vena cava (IVC) in a patient with previous right pneumonectomy, because acute angulation had resulted from the rightward displacement of the right atrium, which could not be followed by the fixed IVC. Accordantly, axillary artery and femoral vein may also be considered as cannulation sites in patients where median sternotomy may be problematic [21].

        It is worth noting that in our review, 6 patients (14, 15, 18, 21, 25 and 29) OPCAB, 3 of them via left thoracotomy (patients 21, 25 and 29). OPCAB, according to recent studies [28, 29], has similar morbidity and mortality rates compared to standard CPB for CABG surgery, but boasts reduced incidence of systemic inflammatory response syndrome, blood clotting and blood loss, while claiming shorter ventilation and recovery periods. In previously pneumonectomised patients therefore, it may hold an advantage over CPB, since these patients already have impaired pulmonary function [30] and are at higher risk for CPB-related complications [10]. Ushijima et al [22] stated that OPCAB reduces postoperative pulmonary complications and eliminates the need for compromise between central venous system and target coronary site exposure.

        There have been objections in the past literature concerning the use of the internal thoracic artery (ITA) to perform CABG in previously pneumonectomised patients [4, 19, 20]. For instance, the ITA may be difficult to harvest from the side of pneumonectomy and the pedicled graft may fail to reach its target site due to heart dislocation. In addition, the ITA may be subjected to excess stress and tension by the hyper-inflated lung. Moreover, harvesting of the ITA on the side of the intact lung may cause damage to the phrenic nerve10, while postoperative pain associated with ITA harvesting may deteriorate pulmonary function [31]. Nonetheless, Stoller et al [18] favoured its use, claiming favorable experience with the graft. Also, Bernet et al [15] suggested harvesting of a skeletonized ITA or performing a “LIMA fissure” technique [32] to alleviate stress on the ITA. Out of 21 CABG operations performed in our review, ITA graft was used in 8 (38%). Postoperative complications were reported in 2 of these cases and in 1 of them the outcome was fatal.

        Prevalence of postoperative complications in the current series was 37% (n = 11), with respiratory failure being the most common (n = 5), requiring prolong ventilation and tracheostomy. This is justified by the reviewed patients’ compromised preoperative pulmonary reserves [23], along with the fact that anatomical changes of the chest may pose challenges on the surgical team, possibly leading to increased pump-related stress or even injury to chest structures [26]. Overall mortality rate in the current series was 13%, slightly less than the 16% reported in the last review by Stoller et al [18], but still high compared to patients with no such a severe comorbidity undergoing CABG or valve surgery [33, 34]. Furthermore, major adverse cardiac and cardiovascular effects were not observed in a significantly higher rate among this cohort of patients. Unfortunately, there is no data to detect the long term prognosis, since most of the cases were focused on early postoperative outcome.

        Conclusion

        In conclusion, the current series extends the previous review by Stoller et al [18] , summarizing the available data on 29 previously pneumonectomised patients who underwent 30 CABG and/or valvular operations. The gathered experience suggests that a carefully planned surgical strategy that incorporates modern techniques to alleviate patient stress, combined with specific standards regarding preoperative and postoperative management, contribute to successfully perform open heart revascularization and/or valvular procedures with acceptable but still high morbidity and mortality rates in previously pneumonectomised patients. Finally, in view of the new era of transfemoral aortic valve insertion (TAVI), this review it is likely to stimulate the existing argument as to whether, in these patients, a TAVI procedure should be preferred to an open aortic valve replacement.

        Declarations

        Authors’ Affiliations

        (1)
        Department of Cardiothoracic Surgery, Patras University School of Medicine

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        © Fragkidis; licensee BioMed Central Ltd. 2012

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