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Comparing use of BIMA in a Y-graft configuration to BIMA with additional radial artery use during CABG: Two institutional study
Journal of Cardiothoracic Surgery volume 10, Article number: A105 (2015)
Arterial grafting has been demonstrated to confer long-term survival advantages to patients undergoing Coronary Artery Bypass Grafting (CABG). Arterial revascularization may be achieved through the sole utilization of sequential Bilateral Internal Mammary Arteries (BIMA) in a Y-graft construct, or the use of BIMAs with additional radial arteries (RA).
We assessed the long-term survival of these two approaches.
Two consecutive series of patients underwent arterial revascularization at two institutions from 2000-2010. In group A, 183 patients underwent CABG with non-sequential BIMA grafting, utilizing the RA for additional targets. In group B, 771 patients underwent solely sequential BIMA grafting in a Y-graft configuration. Patient differences were balanced using a propensity score developed from a logistic regression model with 20 baseline factors. Cox Proportional Hazards Regression was used to adjust for group differences in evaluating survival. In addition, propensity scoring was used to develop two matched cohorts, and survival of these 178 patients was assessed with Kaplan Meier Survival analysis.
Patients in group B were significantly older (65.7 ± 9 vs. 56.6 ± 10; p < 0.0001) with more diabetes (30.6% vs. 6%; p < 0.0001), CHF (21.0% vs. 2.7%; p < 0.0001), Peripheral vascular disease (21.1% vs. 8.2%; p < 0.0001), renal insufficiency (10.5% vs. 0.0%; p < 0.0001) and dialysis (10.4% vs. 0.0%; p < 0.0001). Group A had a higher proportion of patients with left ventricular ejection fraction less than 50% (26.8% vs. 20.9%; p = 0.046). Both groups had equivalent in-hospital mortality (1.0%), anastomotic sites (mean of 4; p = 0.552) and use of off-pump (both > 90%). In Cox analysis using the propensity score, group B had a trend of improved 14-year survival (92% vs 84%; p = 0.059). Kaplan-Meier analysis of the propensity matched sub-groups showed no statistical significance in 14-year survival (93% vs. 89%; p = 0.101).
Overall there was no statistically significant difference in survival between these two approaches to arterial revascularization. A larger cohort is required to fully compare these techniques.
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Glineur, D., Shaw, R., Kuschner, C. et al. Comparing use of BIMA in a Y-graft configuration to BIMA with additional radial artery use during CABG: Two institutional study. J Cardiothorac Surg 10, A105 (2015). https://doi.org/10.1186/1749-8090-10-S1-A105
- Left Ventricular Ejection Fraction
- Coronary Artery Bypass Grafting
- Propensity Score
- Left Ventricular Ejection
- Radial Artery