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  • Meeting abstract
  • Open Access

Lipid metabolism does not influence the expression of proximal aortopathy in bicuspid aortic valve disease

  • 1,
  • 1 and
  • 1
Journal of Cardiothoracic Surgery201510 (Suppl 1) :A65

https://doi.org/10.1186/1749-8090-10-S1-A65

  • Published:

Keywords

  • Lipid Metabolism
  • Triglyceride Level
  • Statin Therapy
  • Aortic Valve Replacement
  • Correlation Pattern

Background/Introduction

Controversy exists regarding the pathogenesis of bicuspid aortic valve (BAV) associated aortopathy. Recent data indicate the potential role of lipid metabolism in the expression of aortopathy.

Aims/Objectives

We aimed to correlate the markers of lipid metabolism with severity of proximal aortopathy in patients with BAV vs. tricuspid aortic valve (TAV) disease.

Method

A total of 458 consecutive patients (mean age 64 ± 11 years, 68% male) underwent aortic valve replacement (AVR) with/without proximal aortic surgery from January,2008 through December,2014. All patients undergoing combined procedures (e.g., AVR+CABG) were excluded. Only patients in whom proximal aortic dimensions were defined by preoperative CT/MRI and/or TOE were included. Correlation analysis was performed between markers of lipid metabolism (i.e., cholesterol, LDL, HDL, and triglyceride) and maximal diameter of the proximal aorta in BAV subgroup (n = 273) vs. TAV subgroup (n = 185). Moreover, we compared correlation patterns between markers of lipid metabolism and maximal aortic diameter in BAV insufficiency (n = 46) vs. BAV stenosis (n = 227) cohorts. Logistic regression was performed to identify risk factors for proximal aortic diameter >40 mm in BAV and TAV subgroups.

Results

No correlation was found between markers of lipid metabolism and proximal aortic diameter in BAV subgroup (r = -0.1, p = 0.1) and TAV subgroup (r = 0.006, p = 0.9). No significant differences in correlation patterns were found between markers of lipid metabolism and maximal aortic diameter in BAV insufficiency (r = 0.03, p = 0.8) vs. BAV stenosis (r = -0.1, p = 0.1) cohorts. Logistic regression analysis revealed triglyceride levels (HR 1.4, p = 0.05) and statin therapy (HR 0.4, p = 0.03) as predictors of proximal aortic diameter >40 mm in TAV subgroup only.

Discussion/Conclusion

Our study demonstrates no linear correlation between markers of lipid metabolism and proximal aortic diameters in a surgical cohort of BAV and TAV patients. Statin therapy and triglyceride levels influence significantly proximal aortic diameter in patients with TAV, but not with BAV disease.

Authors’ Affiliations

(1)
Department of Cardiac Surgery, Central Clinic Bad Berka, Germany

Copyright

© Gross et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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