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Figure 7 | Journal of Cardiothoracic Surgery

Figure 7

From: Neutrophil mediated smooth muscle cell loss precedes allograft vasculopathy

Figure 7

Neutrophils mediate SMC loss. (a) C3H allograft transplanted into a B6 recipient harvested at 1d post-transplant with dramatic loss of SMC; (b) C3H allograft transplanted into NФ depleted B6 recipient at 1d post-transplant showing partial preservation of medial SMC; (c) C3H allograft transplanted into B6 recipient at 1wk post-transplant exhibits significant SMC loss; (d) C3H allograft transplanted into NФ depleted B6 recipient at 1wk post-transplant with SMC present in the media; (e) mean ± SEM medial SMC counts for untreated control and NФ depleted recipients at 1d and 1wk post-transplant. Arrow heads demarcate the media. Arrows indicate medial SMC. n = 3-6 per time point.

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