Table 1 Experimental results

NZW rabbits

n = 21

n = 17

P

Weight (kg) at baseline

3.15 ± 0.25

3.13 ± 0.23

0.80

Weight (kg) at 4 weeks

3.30 ± 0.3

3.27 ± 0.28

0.75

Mortality (%)

9/21 (42.9%)

5/17 (29.4%)

0.20

ECG outcomes

P

Abnormal ECG

15-20 min

Immediately

n/a

ST elevation (mm)

2.01 ± 0.84

1.90 ± 0.71

0.68

Blood biochemistry

P

Troponin (ng/ml) baseline

0.06 ± 0.06

0.05 ± 0.09

0.70

Troponin (ng/ml) (24 h)

47.6 ± 64.6

44.5 ± 57.7

0.88

AST baseline(U/L)

36.8 ± 21.4

33.2 ± 20.4

0.60

AST (U/L)*

110.0 ± 87.3

105.8 ± 87.6

0.88

LDH baseline(U/L)

169.4 ± 112.2

176.2 ± 101.8

0.85

LDH(U/L)*

967.4 ± 976.9

913.3 ± 820.8

0.85

CPK baseline (U/L)

1,072.0 ± 367.7

1,007.8 ± 287.2

0.55

CPK (U/L)*

6,725.8 ± 4,642.1

6,386.3 ± 3,921.4

0.81

CK -(MB) baseline (ng/ml)

0.87 ± 0.42

0.82 ± 0.33

0.68

CK -(MB) (ng/ml)*

2.88 ± 1.68

2.78 ± 1.37

0.84

Post-infarct outcomes

P

Abnormal Q waves

All surviving animals

All surviving animals

n/a

Infarct size, cm (range)

0.92 ± 0.54 (0.3-2.0)

0.86 ± 0.35(0.5-1.7)

0.68

Baseline LVEDP (mmHg)

6.7 ± 1.8

6.2 ± 1.7

0.39

4-week LVEDP (mmHg)

12.9 ± 2.3

12.7 ± 2.0

0.78