Skip to main content

Table 1 The mean cell viabilities (%) after treatment with amiodorane alone and with antioxidant agents

From: May toxicity of amiodarone be prevented by antioxidants? A cell-culture study

  Cell viability % (Mean ± SD)
Concentration Amiodarone Amiodarone + Vitamin Ca Amiodarone + NACa p*
20 μM 117.10 ± 50.75 131.31 ± 36.62 133.86 ± 38.91 0.884
40 μM 130.49 ± 48.70 122.12 ± 24.27 91.83 ± 41.86 0.166
60 μM 97.73 ± 48.08 108.25 ± 16.85 133.65 ± 28.12 0.172
80 μM 81.39 ± 64.45 122.00 ± 19.94 120.34 ± 52.70 0.414
100 μM 59.41 ± 16.43 128.43 ± 30.94 108.74 ± 39.04 0.011
120 μM 26.66 ± 7.40 116.63 ± 23.81 74.93 ± 26.31 0.001
140 μM 19.63 ± 6.81 88.11 ± 29.38 80.33 ± 43.47 0.003
160 μM 16.92 ± 6.46 111.55 ± 24.02 70.18 ± 23.15 0.001
180 μM 14.91 ± 4.32 68.52 ± 25.39 48.58 ± 12.21 0.002
  1. a Vitamin C and NAC were added at one-fold equimolar dose of amiodarone concentrations.
  2. *Kruskal-Wallis test.
  3. NAC: N-acetyl cysteine.