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Table 1 The mean cell viabilities (%) after treatment with amiodorane alone and with antioxidant agents

From: May toxicity of amiodarone be prevented by antioxidants? A cell-culture study

 

Cell viability % (Mean ± SD)

Concentration

Amiodarone

Amiodarone + Vitamin Ca

Amiodarone + NACa

p*

20 μM

117.10 ± 50.75

131.31 ± 36.62

133.86 ± 38.91

0.884

40 μM

130.49 ± 48.70

122.12 ± 24.27

91.83 ± 41.86

0.166

60 μM

97.73 ± 48.08

108.25 ± 16.85

133.65 ± 28.12

0.172

80 μM

81.39 ± 64.45

122.00 ± 19.94

120.34 ± 52.70

0.414

100 μM

59.41 ± 16.43

128.43 ± 30.94

108.74 ± 39.04

0.011

120 μM

26.66 ± 7.40

116.63 ± 23.81

74.93 ± 26.31

0.001

140 μM

19.63 ± 6.81

88.11 ± 29.38

80.33 ± 43.47

0.003

160 μM

16.92 ± 6.46

111.55 ± 24.02

70.18 ± 23.15

0.001

180 μM

14.91 ± 4.32

68.52 ± 25.39

48.58 ± 12.21

0.002

  1. a Vitamin C and NAC were added at one-fold equimolar dose of amiodarone concentrations.
  2. *Kruskal-Wallis test.
  3. NAC: N-acetyl cysteine.
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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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