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Table 1 Summary of studies on heart persufflation

From: Persufflation (gaseous oxygen perfusion) as a method of heart preservation

Year Author(s) [Ref.] Approach for PSFa WIT (min) Duration of PSF (hours) Model(s) Transplant follow-up Gas used Temp (°C) Primary endpoint
No transplant         
1902 Magnus R [11] A - ≤ 1.15 Cat - O2, H2, CO2 24-28 Cardiac activity during PSF
1958 Burns et al. [13] A - > 3 Rabbit - Carbogenb, N2 37 Cardiac activity during PSF
1959 Sabiston et al. [14] A - < 8 Dog - Carbogenb, N2 37 Cardiac activity during PSF and after reperfusion
1960 Talbert et al. [15] R - 2-7 Dog - Carbogenb 37 Cardiac activity during PSF and reperfusion
1966 Camishion et al. [18] R - < 7 Dog, Pig - O2, N2 38 Cardiac activity during PSF
1966 Gabel et al. [20] A - 10 Cat - Carbogenb 40 Cardiac activity and metabolic profile during PSF
1968 Lochner et al. [21] A - < 1.5 Guinea pig, Rat - Carbogenb 4-37 Cardiac activity, WOOCR and metabolic profile during PSF
2001 Fischer J [28] A 16 3.3 Pig (DCD) - O2 0-1 Coronary endothelial function
2004 Fischer J [30] A 16 3.3 Pig (DCD) - O2 0-1 Coronary endothelial function
Transplant studies         
1998 Kuhn-Regnier et al. [23] A - 14.5 Pig 3 hours O2 0-1 Cardiac function and metabolic profile post-allotransplant (orthotopic)
1998 Fischer et al. [24] A - 14.2 Pig 3-4 hours O2 0-1 Cardiac function and metabolic profile post-allotransplant (orthotopic)
2000 Kuhn-Regnier et al. [26] A - 14.5 Pig 3 hours O2 0-1 Cardiac function and metabolic profile post-allotransplant (orthotopic)
2003 Yotsumoto et al. [27] A 16.7 2.3 Pig (DCD) 3 hours O2 0-1 Cardiac function and metabolic profile post-allotransplant (orthotopic)
2004 Kuhn-Regnier et al. [29] A - 14 Pig 7 days O2 0-1 Endothelial and myocardial cell function post-allotransplant (heterotopic)
  1. Superscripts: aEither anterograde via the coronary arteries (denoted by ‘A’) or retrograde via the coronary sinus and possibly anterior cardiac veins (denoted by ‘R’); bCarbogen is defined as a gas mixture composed of 95% oxygen and 5% CO2. Abbreviations: DCD, donation after cardiac death; PSF, persufflation; WOOCR, whole organ oxygen consumption rate.