Table 1 Summary of studies on heart persufflation
From: Persufflation (gaseous oxygen perfusion) as a method of heart preservation
Year | Author(s) [Ref.] | Approach for PSFa | WIT (min) | Duration of PSF (hours) | Model(s) | Transplant follow-up | Gas used | Temp (°C) | Primary endpoint |
|---|---|---|---|---|---|---|---|---|---|
No transplant | Â | Â | Â | Â | Â | Â | Â | Â | |
1902 | Magnus R [11] | A | - | ≤ 1.15 | Cat | - | O2, H2, CO2 | 24-28 | Cardiac activity during PSF |
1958 | Burns et al. [13] | A | - | > 3 | Rabbit | - | Carbogenb, N2 | 37 | Cardiac activity during PSF |
1959 | Sabiston et al. [14] | A | - | < 8 | Dog | - | Carbogenb, N2 | 37 | Cardiac activity during PSF and after reperfusion |
1960 | Talbert et al. [15] | R | - | 2-7 | Dog | - | Carbogenb | 37 | Cardiac activity during PSF and reperfusion |
1966 | Camishion et al. [18] | R | - | < 7 | Dog, Pig | - | O2, N2 | 38 | Cardiac activity during PSF |
1966 | Gabel et al. [20] | A | - | 10 | Cat | - | Carbogenb | 40 | Cardiac activity and metabolic profile during PSF |
1968 | Lochner et al. [21] | A | - | < 1.5 | Guinea pig, Rat | - | Carbogenb | 4-37 | Cardiac activity, WOOCR and metabolic profile during PSF |
2001 | Fischer J [28] | A | 16 | 3.3 | Pig (DCD) | - | O2 | 0-1 | Coronary endothelial function |
2004 | Fischer J [30] | A | 16 | 3.3 | Pig (DCD) | - | O2 | 0-1 | Coronary endothelial function |
Transplant studies | Â | Â | Â | Â | Â | Â | Â | Â | |
1998 | Kuhn-Regnier et al. [23] | A | - | 14.5 | Pig | 3 hours | O2 | 0-1 | Cardiac function and metabolic profile post-allotransplant (orthotopic) |
1998 | Fischer et al. [24] | A | - | 14.2 | Pig | 3-4 hours | O2 | 0-1 | Cardiac function and metabolic profile post-allotransplant (orthotopic) |
2000 | Kuhn-Regnier et al. [26] | A | - | 14.5 | Pig | 3 hours | O2 | 0-1 | Cardiac function and metabolic profile post-allotransplant (orthotopic) |
2003 | Yotsumoto et al. [27] | A | 16.7 | 2.3 | Pig (DCD) | 3 hours | O2 | 0-1 | Cardiac function and metabolic profile post-allotransplant (orthotopic) |
2004 | Kuhn-Regnier et al. [29] | A | - | 14 | Pig | 7 days | O2 | 0-1 | Endothelial and myocardial cell function post-allotransplant (heterotopic) |