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Table 2 Biomarker plasma concentrations

From: The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery

         

p valuesa

 

Variable

Pre-op

Start-op

Heparin

Start CPB/30’ Hep

End CPB/Anastomosis

1 h ICU

24 h ICU

Between groups

Between timepoints

Interaction

SP-D [ng/mL] - Median (IQR)

 

0.068

0.001

0.014

CABG

4.15 (2.88-7.99)

4.71 (2.83-7.92)

4.59 (3.00-13.36)

6.20 (3.19-13.44)

8.96 (7.32-14.12)

8.71 (5.25-13.91)

5.69 (2.99-11.46)

   

OPCAB

4.39 (1.97-8.08)

3.51 (2.67-6.95)

4.27 (2.61-6.75)

4.14 (2.48-5.26)

4.91 (2.07-10.72)

5.08 (3.43-7.39)

3.99 (0.59-6.72)

   

CC16 [ng/mL] - Median (IQR)

      

0.988

<0.001

0.068

CABG

5.41 (4.38-9.21)

6.45 (4.25-9.45)

8.15 (5.88-13.56)

10.36 (6.18-16.79)

10.47 (6.50-14.34)

7.95 (4.33-13.23)

4.66 (3.92-9.18)

   

OPCAB

5.14 (5.59-15.06)

7.95 (4.79-11.09)

10.61 (7.62-14.02)

8.33 (6.22-11.64)

8.34 (5.64-13.42)

7.15 (4.57-14.50)

3.92 (2.28-7.43)

   

Elastase [ μg/mL] - Median (IQR)

      

0.002

<0.001

<0.001

CABG

2.16 (1.63-3.19)

1.87 (1.61-3.46)

2.68 (2.03-3.13)

4.09 (2.32-4.95)

29.1 (14.3-2.24)

37.7 (14.0-55.9)

16.7 (7.63-24.6)

   

OPCAB

1.43 (1.17-2.85)

2.17 (1.61-3.46)

2.12 (1.25-2.86)

2.89 (2.12-3.47)

4.02 (2.24-4.90)

5.13 (3.13-6.95)

12.9 (7.97-20.9)

   

MPO [ng/mL] - Median (IQR)

      

0.025

<0.001

<0.001

CABG

37 (28–45)

28 (23–48)

441 (334–527)

507 (401–571)

191 (133–310)

134 (80–170)

52 (45–58)

   

OPCAB

41 (32–50)

38 (32–45)

367 (314–386)

360 (319–388)

172 (101–304)

109 (64–148)

59 (48–80)

   
  1. IQR, inter quartile range; a Two-way mixed ANOVA.