Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma

Table 4 Validation of the 13 differentially expressed genes in 41 patients with AIS LPA

Gene name	Fold regulation	Up/down	P^※	HR	Correlation coefficient^▲	P^*
claudin 7 (CLDN7)	0.0691	Down	<0.01	0.432	0.68	<0.01
SMAD specific E3 ubiquitin-- protein ligase2 (SMURF2)	5.8528	Up	<0.01	2.422	0.58	<0.01
claudin 1 (CLDN1)	0.0344	Down	0.001	1.731	0.44	<0.01
FBJ murine osteosarcoma viral oncogene homolog (c-fos)	7.8182	Up	0.02	0.75	0.64	<0.01
met-proto-oncogene (MET)	5.5674	Up	<0.01	0.455	0.26	0.21
Vascular cell adhesion molecule 1 (VCAM1)	0.0593	Down	<0.01	2.156	0.25	0.23
WNT inhibitory factor 1 (WIF1)	0.1727	Down	<0.01	1.727	0.20	0.45
Fibroblast growth factor receptor 1 (FGFR1)	8.3246	Up	0.001	0.611	0.14	0.66
Wingless-typeMMTVintegrationsitefamilymember 2 (wnt 2)	6.1408	Up	<0.01	0.497	0.18	0.68
Matrix metallopeptidase 2 (MMP-2)	9.6869	Up	0.038	1.321	−0.19	0.59
Suppressor of cytokinesignaling1 (SOCS1)	5.0212	Up	0.001	1.671	0.05	0.78
Mucin 4, cell surface associated (MUC4)	0.1278	Down	0.012	0.717	0.02	0.82
Sp1 transcription factor (sp1)	0.1567	Down	0.049	0.793	0.01	0.89

P^※ values were estimated by univariate Cox regression analysis of the microarray data.
^▲: Correlation Coefficient for Microarray Results vs. Real-Time RT-PCR Results.
P^*values for the correlation coefficients were estimated by Spearman’s rank-correlation test.

ISSN: 1749-8090