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Table 4 Validation of the 13 differentially expressed genes in 41 patients with AIS LPA

From: Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma

Gene name Fold regulation Up/down P HR Correlation coefficient P*
claudin 7 (CLDN7) 0.0691 Down <0.01 0.432 0.68 <0.01
SMAD specific E3 ubiquitin-- protein ligase2 (SMURF2) 5.8528 Up <0.01 2.422 0.58 <0.01
claudin 1 (CLDN1) 0.0344 Down 0.001 1.731 0.44 <0.01
FBJ murine osteosarcoma viral oncogene homolog (c-fos) 7.8182 Up 0.02 0.75 0.64 <0.01
met-proto-oncogene (MET) 5.5674 Up <0.01 0.455 0.26 0.21
Vascular cell adhesion molecule 1 (VCAM1) 0.0593 Down <0.01 2.156 0.25 0.23
WNT inhibitory factor 1 (WIF1) 0.1727 Down <0.01 1.727 0.20 0.45
Fibroblast growth factor receptor 1 (FGFR1) 8.3246 Up 0.001 0.611 0.14 0.66
Wingless-typeMMTVintegrationsitefamilymember 2 (wnt 2) 6.1408 Up <0.01 0.497 0.18 0.68
Matrix metallopeptidase 2 (MMP-2) 9.6869 Up 0.038 1.321 −0.19 0.59
Suppressor of cytokinesignaling1 (SOCS1) 5.0212 Up 0.001 1.671 0.05 0.78
Mucin 4, cell surface associated (MUC4) 0.1278 Down 0.012 0.717 0.02 0.82
Sp1 transcription factor (sp1) 0.1567 Down 0.049 0.793 0.01 0.89
  1. P values were estimated by univariate Cox regression analysis of the microarray data.
  2. : Correlation Coefficient for Microarray Results vs. Real-Time RT-PCR Results.
  3. P*values for the correlation coefficients were estimated by Spearman’s rank-correlation test.