- Oral presentation
- Open Access
Toxic chemical element barium content in different biosubstrates of children with congenital heart diseases
© Koval et al; licensee BioMed Central Ltd. 2013
- Published: 11 September 2013
- Congenital Heart Disease
- Congenital Heart
- Septal Defect
- Toxic Chemical Element
Number of studies indicates on possible role of toxic substances in development of heart malformations during cardiogenesis. The aim of our research is studying of toxic element barium content in different biosubstrates of children with CHD.
29 patients (17 (58,6%) boys and 12 (41,6%) girls), aged from 14 days to 17 years (medium age: 26 month±2 month) old with CHD were examined by the spectral analysis of toxic element barium in intraoperative (23) and autopsy (6) biopsies of endocardium (22), myocardium (26), pericardium (7), aorta (10), skin (8), subcutaneous fat (8), intercostal muscles (24), fascia (2), kidneys (5), brain (2) and hair (9) by methods of the atomic emission spectrometry in the inductively coupled plasma and atomic absorption spectrometry with electrothermal atomization.
A comparative analysis of barium level in different biosubstrates demonstrated it’s highest content (числа) in muscle tissue (myocardium, smooth muscle of the vessel walls, cross-striated rib muscles). Whereas in other tissues the concentration was decreased or absent. Barium content exceeded toxic level in heart tissues of 72.4% of patients. The excess degree of barium content depended on biopsy topics, namely, in aorta coarctation place, valve atresia place, septal defect its level was in two, ten or more times higher than in normal heart area or great vessel area. Dependence between the barium excess degree content in the heart tissue and severity of malformation or its combinations was also established: children with exceeding level of barium in the heart tissues had significantly more (p <0.05) of combined complex CHD.
Barium affinity to the myocardium, blood vessels smooth muscles and striated skeletal muscles was confirmed. Spectrum of barium content depends on the type and severity of the defect and biopsy point. Received data indicate on possible role of barium in cardiogenesis malformation, that needs deeper investigation.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.