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Left heart chambers reverse remodeling after combined CABG and mitral repair
Journal of Cardiothoracic Surgery volume 8, Article number: O215 (2013)
Up to 30 % of all ischemic heart disease patients present with some degree of ischemic mitral regurgitation. It is proven that any grade adversely affects long-term outcomes. Surgical revascularization and restoration of the valvular function both trigger left atrial and ventricular reverse remodeling and improve the prognosis.
To evaluate the actual reverse remodeling and its influence on the outcomes we perform follow-up on 71 patients subjected to combined surgical revascularization and mitral valve repair for mild to moderate ischemic mitral regurgitation. Mean follow-up was 28 (6 to 52) months. Left atrial and ventricular dimensions and volumes were evaluated preoperatively and at the follow-up.
The mean effective ejection fraction increased from 18 ± 6% to 39 ± 13% (p << 0.05) at the follow-up. Left ventricular end-systolic volume index decreased from 44 ± 24 ml/m2 to 39 ± 26 ml/m2 (p = 0.002). Significant left ventricular reverse remodeling (≥ 15% reduction of LVESVI) was observed in 55 % of all survivors. Recurrent IMR was detected in only 2.8% (2/71) of the evaluated patients. Left atrial volume index decreased from 43 ± 15 ml/m2 to 36 ± 14 ml/m2 (p = 0.000003) and left atrial reverse remodeling was significant for 57 % of all survivors.
Despite the advanced process of left atrial and ventricular remodeling in the setting of chronic ischemic mitral regurgitation, left chambers can be effectively addressed by combined revascularization and mitral repair.
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Slavov, M., Panayotov, P., Panayotova, D. et al. Left heart chambers reverse remodeling after combined CABG and mitral repair. J Cardiothorac Surg 8, O215 (2013). https://doi.org/10.1186/1749-8090-8-S1-O215
- Left Atrial
- Volume Index
- Mitral Valve Repair
- Reverse Remodel
- Ischemic Mitral Regurgitation