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  • Open Access

Surgical treatment for bronhial carcinoid tumors prognostic factors for long-term outcome

Journal of Cardiothoracic Surgery20138 (Suppl 1) :O231

https://doi.org/10.1186/1749-8090-8-S1-O231

  • Published:

Keywords

  • Histology Type
  • Median Survival Time
  • Carcinoid Tumor
  • Hsp27 Expression
  • Main Bronchus

Background

The aim of study was to study the prognostic factors after surgery with curative intend for pulmonary carcinoid tumors - typical carcinoid (TCs) and atypical carcinoid (AtCs).

Methods

Surgically resected specimen (men n=59;women n=72, age 48±15) from 111 TC (84.7%) and 20 AtC (15.3%) patients were studied. The histological type, T-status, N-status (TC - 94 N0, 17 N1/2; AtC - 16 N0, 4 N1), pTNM stage (TC-I n=81, II n=17, III+IV=13; AtC-I n=12, II-IV n=8), surgery (55 simple lobectomies, 16 bilobectomies, 24 pneumonectomies (4 extended), 15 segmentectomies, 16 sleeve lobectomy (in 2 of them combined with sleeve resection of pulmonary artery), 5 sleeve resection of main bronchus), and immunohistochemical expression (on 64 TCs and 13 AtCs) of p-HspB5, Hsp27 and mTOR were evaluated. Kaplan-Meier, Wilcoxon, Cox regression analyses were the statistical methods used.

Results

The overall 5-, 10- and 15-year survival for TCs were 84%, 70% and 62% respectively; and for AtCs–53% and 0%. The difference in mean survival time between TCs (14 years) and AtCs (7 years) was significant (p=0.004).The median survival time was significantly longer in N0 status (N0-213 months,N1/2-54,p=0.002), in I and II pTNM status (I/II-213 months, III/IV-27,p=0.020) and in cases positive for mTOR (p=0.035). T status, p-HspB5, Hsp27 expression were not statistically significant factors for survival (p>0.05).The Cox analysis confirmed the prognostic significance of histology type (HR 3.32;p=0.007), N status (HR 3.51;p=0.014) and pTNM stage (HR 11.27;p<0.001).

Conclusion

Postoperative survival is significantly related to the histology type, N status, pTNM stage and mTOR expression.

Authors’ Affiliations

(1)
Thoracic Surgery, Saint Sophia University Hospital for Pulmonary Diseases, Medical University, Sofia, Bulgaria
(2)
Pneumology, Saint Sophia University Hospital for Pulmonary Diseases, Medical University, Sofia, Bulgaria

Copyright

© Petrov et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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