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Plasma cholinesterase activity in children with infective endocarditis


Although pre-existing heart disease in children is the most frequent predisposing factor for infective endocarditis (IE), we reporte 6 children of IE with no apparent pre-existing cardiac disease.


Our study included six patients with acquired infection from central catheter; the microbial pathogens were Streptococcus viridans (n=3) and Staphyloccocus aureus (n=3). The diagnosis of IE was based on positive blood culture (2 positive cultures of blood samples drawn > 12 hours), evidence of endocardial involvement (positive ECHO), measuring raised erythrocyte sedimentation rate and plasma cholinesterase (PChE) activity. We measured PChE activity (µmol min-1ml-1) in children with IE (group A, n=6) and in IE-free children (group B, n=10). For determination of PChE activity vein blood samples were collected and stored at -20°C until analyzed. PChE activity was determined by the spectrophotometric method of Ellman using butyryltiocholine as the substract (Sigma Chemical Co., St.Luis, Mo, USA). Statistical analysis was made by Student’s t-test.


In group A of examined children with IE we measured decreased PChE activity (1.89 ± 0,24) relation to patients of control group B (3,97 ± 0,20).


Our study indicates that PChE activity can be also an important parameter for the diagnosis of IE.

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Correspondence to LJ Popovic.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Popovic, L., Alavuk, S. & Kovacevic, T. Plasma cholinesterase activity in children with infective endocarditis. J Cardiothorac Surg 8 (Suppl 1), P177 (2013).

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