Figure 6

Effect of SEA0400 in cardioplegia on recovery of LV function in isolated hearts. A) Maximum LV developed pressure (LVDP) determined from the intra-ventricular balloon recordings before arrest (baseline) and after reperfusion. B) Maximum dP/dt + and dP/dt-. C) LV work estimated by the area between the end-systolic and end-diastolic pressure-volume relationships. Data points represent mean ± SEM, * = p < 0.001, ** = p < 0.0001 for cardioplegia wihout SEA0400 (n = 6) vs. cardioplegia with SEA0400 (n = 7). Baseline values for the two groups were not significantly different.