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Figure 3 | Journal of Cardiothoracic Surgery

Figure 3

From: Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway

Figure 3

Sorafenib inhibits the over expression of growth factors in myocardium. Tissue levels are determined by ELISA normalized to total protein content (pg/mg). A. Sorafenib abolishes the over expression of myocardial PDGF-BB levels in banded animals (p < 0001, ***). B. Sorafenib suppresses over expression of the pro-fibrotic growth factor TGFβ1 in myocardium in banded animals (p < 0001, ***). All measurements were performed in duplicate.

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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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