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Figure 4 | Journal of Cardiothoracic Surgery

Figure 4

From: Multikinase inhibitor sorafenib prevents pressure overload-induced left ventricular hypertrophy in rats by blocking the c-Raf/ERK1/2 signaling pathway

Figure 4

Sorafenib prevents phosphorylation of c-Raf and ERK1/2 in myocardium following AB. Left panel: representative Western blot for phosphorylated (upper band) and total (lower band) kinases from ventricle tissue. Right panel: ratios of phosphorylated to total kinases are presented as histograms. A. c-Raf phosphorylation is inhibited by sorafenib treatment in banded animals (p < 0001, ***). B. ERK1/2 phosphorylation is blocked by sorafenib treatment in banded animals (p < 0001, ***).

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Journal of Cardiothoracic Surgery

ISSN: 1749-8090

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