Sorafenib prevents phosphorylation of c-Raf and ERK1/2 in myocardium following AB. Left panel: representative Western blot for phosphorylated (upper band) and total (lower band) kinases from ventricle tissue. Right panel: ratios of phosphorylated to total kinases are presented as histograms. A. c-Raf phosphorylation is inhibited by sorafenib treatment in banded animals (p < 0001, ***). B. ERK1/2 phosphorylation is blocked by sorafenib treatment in banded animals (p < 0001, ***).