| |
Before CBP
|
After CPB
|
|---|
| |
Custodiol
|
Custodiol-N
|
Custodiol
|
Custodiol-N
|
|---|
|
HR (1/min)
|
122.5 ± 8.1
|
144.3 ± 8.4
|
130.1 ± 4.6
|
157.5 ± 13.1
|
|
MAP (mmHg)
|
89 ± 3
|
79 ± 5
|
77 ± 11
|
67 ± 3
|
|
CO (l/min)
|
2.1 ± 3.9
|
2.3 ± 0.4
|
1.9 ± 0.2
|
2.3 ± 0.2
|
|
CBF (ml/min)
|
41.3 ± 6.1
|
44.5 ± 3.8
|
26.2 ± 2.8#
|
58 ± 7.0*
|
|
MPO (ng/ml)
|
0.9 ± 0.3
|
1.1 ± 0.1
|
4.3 ± 2.2#
|
3.4 ± 0.4#*
|
|
Nitrite (ng/ml)
|
1.2 ± 0.3
|
1.6 ± 0.3
|
0.5 ± 0.2#
|
1.1 ± 0.3*
|
- HR: heart rate, MAP: mean arterial pressure, CO: cardiac output, CBF: coronary blood flow, MPO: plasma myeloperoxidase. All values are given as mean ± SEM. *: p < 0.05 vs. Custodiol, #: p < 0.05 vs. baseline.
