Table 1 Design and characteristic of trials included in the meta-analysis
Source | Publication year | Country | No. of patients | Sex (male, %) | Mean age (year) | History of disease | Previous CVD (%) | Intervention | Control | Follow-up (year) | Jadad score |
|---|---|---|---|---|---|---|---|---|---|---|---|
2004 | US | 334 | 67.0 | 72.6 | Symptomatic carotid artery stenosis of at least 50 % of the luminal diameter or an asymptomatic stenosis of at least 80 % | 80.7 | Endarterectomy | Carotid artery stenting with an embolic protection device | 3 | 2 | |
MGM Steinbauer [20] | 2008 | Germany | 87 | NG | 68.5 | Symptomatic high-grade internal carotid artery stenosis of at least 70 % | 43.7 | Endarterectomy | Carotid artery stenting | 5.4 | 3 |
WH Brooks [21] | 2001 | US | 104 | NG | 68.0 | Symptomatic carotid artery stenosis of at least 70 % | 67.3 | Endarterectomy | Carotid artery stenting | 2 | 4 |
2006 | France | 520 | 75.2 | 69.7 | Symptomatic carotid artery stenosis of at least 60 % | 11.9 | Endarterectomy | Carotid artery stenting | 0.5 | 4 | |
ICSS Investigators [24] | 2010 | UK | 1710 | 70.5 | 70.0 | Symptomatic carotid artery stenosis of at least 50 % | 18.0 | Endarterectomy | Carotid artery stenting | 0.3 | 4 |
2006 | Germany, Austria, and Switzerland | 1183 | 71.8 | 67.9 | Symptomatic carotid artery stenosis of at least 50 % | 22.6 | Endarterectomy | Carotid artery stenting | 2 | 4 | |
MJ Alberts [27] | 2001 | UK | 219 | NG | NG | Symptomatic carotid artery stenosis of 60–99 % | NA | Endarterectomy | Carotid artery stenting | 1 | 2 |
The CREST Investigators [28] | 2010 | US and Canada | 2502 | 65.1 | 69.0 | carotid artery stenosis of at least 50 % | 43.7 | Endarterectomy | Carotid artery stenting | 2.5 | 4 |
2001 | Europe, Australia, and Canada | 504 | 69.5 | 67.0 | carotid artery stenosis | 18.0 | Endarterectomy | Endovascular treatment | 5 | 3 |