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Table 1 Design and characteristic of trials included in the meta-analysis

From: Carotid endarterectomy versus carotid angioplasty for stroke prevention: a systematic review and meta-analysis

Source Publication year Country No. of patients Sex (male, %) Mean age (year) History of disease Previous CVD (%) Intervention Control Follow-up (year) Jadad score
SAPPHIRE Investigators [18, 19] 2004 US 334 67.0 72.6 Symptomatic carotid artery stenosis of at least 50 % of the luminal diameter or an asymptomatic stenosis of at least 80 % 80.7 Endarterectomy Carotid artery stenting with an embolic protection device 3 2
MGM Steinbauer [20] 2008 Germany 87 NG 68.5 Symptomatic high-grade internal carotid artery stenosis of at least 70 % 43.7 Endarterectomy Carotid artery stenting 5.4 3
WH Brooks [21] 2001 US 104 NG 68.0 Symptomatic carotid artery stenosis of at least 70 % 67.3 Endarterectomy Carotid artery stenting 2 4
EVA-3S Investigators [22, 23] 2006 France 520 75.2 69.7 Symptomatic carotid artery stenosis of at least 60 % 11.9 Endarterectomy Carotid artery stenting 0.5 4
ICSS Investigators [24] 2010 UK 1710 70.5 70.0 Symptomatic carotid artery stenosis of at least 50 % 18.0 Endarterectomy Carotid artery stenting 0.3 4
The SPACE Collaborative Group [25, 26] 2006 Germany, Austria, and Switzerland 1183 71.8 67.9 Symptomatic carotid artery stenosis of at least 50 % 22.6 Endarterectomy Carotid artery stenting 2 4
MJ Alberts [27] 2001 UK 219 NG NG Symptomatic carotid artery stenosis of 60–99 % NA Endarterectomy Carotid artery stenting 1 2
The CREST Investigators [28] 2010 US and Canada 2502 65.1 69.0 carotid artery stenosis of at least 50 % 43.7 Endarterectomy Carotid artery stenting 2.5 4
CAVATAS Investigators [29, 30] 2001 Europe, Australia, and Canada 504 69.5 67.0 carotid artery stenosis 18.0 Endarterectomy Endovascular treatment 5 3
  1. CVD cardiovascular disease, NA not available