Impact of prophylactic administration of Levosimendan on short-term and long-term outcome in high-risk patients with severely reduced left-ventricular ejection fraction undergoing cardiac surgery – a retrospective analysis

Table 3 Linear modeling for preoperative predictors influencing survival 30 days postoperatively, postoperative atrial fibrillation and postoperative acute kidney injury

Responses	30-days survival			Postoperative AF within 24h			Postoperative acute kidney injury
Parameter	Coefficient	Standard error	p-Value	Coefficient	Standard error	p-Value	Coefficient	Standard error	p-Value
Prophylactic LS	0.99	0.64	0.12	0.86	0.42	0.038	-1.37	0.53	0.0094
Preoperative IABP	0.40	0.69	0.56	2.19	0.70	0.0017	-1.69	0.68	0.013
Intraoperative IABP	-0.58	0.89	0.51	0.91	0.76	0.23	0.29	0.77	0.71
Postoperative IABP	-2.36	1.03	0.022	0.12	1.04	0.91	1.83	1.03	0.08
Aortic cross clamp time (log)	-1.04	0.84	0.21	1.40	0.57	0.014	1.45	0.64	0.024
EuroSCORE II (log)	-1.12	0.35	0.0012	-0.06	0.21	0.77	0.05	0.21	0.82
BMI (log)	-2.87	1.71	0.093	1.02	1.46	0.48	1.69	1.52	0.26
Preoperative admission to ICU	-0.34	0.66	0.60	0.42	0.59	0.48	0.95	0.59	0.11
Preoperative TNI	-0.09	0.68	0.90	-1.87	0.70	0.0074	-0.39	0.60	0.52
Preoperative CRP (log)	0.04	0.16	0.79	0.03	0.12	0.80	0.16	0.13	0.20
Preoperative white blood cell count (log)	-0.20	0.82	0.81	0.43	0.61	0.48	0.62	0.70	0.38

Multivariate regression analysis using generalized linear models was performed for the responses’30-days survival’, ‘postoperative new onset AF’ and ‘postoperative acute kidney injury’. LS has no significant effect on 30-days survival but contributes significantly to postoperative AF and significantly reduces postoperative acute kidney injury
Abbreviations: AF: Atrial fibrillation, BMI Body-mass index, CRP C-reactive protein, IABP Intra-aortic balloon pump, ICU Intensive care unit, LS Levosimendan, TNI Troponin-I

ISSN: 1749-8090