Fig. 6

Immunohistochemical features in cardiac allograft exposed with Thrombomodulin (TM) or normal saline. a, b Results of double immunostaining of myocardium (a) and coronary arteries (b) in cardiac allografts obtained 2 weeks after transplantation from TM-exposed or untreated recipients (original magnification of all panels, × 40). c, d The right-hand graphs show the number of infiltrating CD4⁺ and Foxp3⁺ cells in an area of 400 μm × 400 μm of myocardium (c) and coronary arteries (d) in cardiac allograft from each group. nTx, untreated. *p < 0.001 for difference between two groups