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Table 2 Multivariate analysis of factors predicting overall survival

From: Neutrophil-lymphocyte ratio predicts recurrence in patients with resected stage 1 non-small cell lung cancer

Factors

Univariate

(P-value)

Multivariate

(P-value)

Risk ratio

95% CI

Sex (male vs. female)

< 0.001

< 0.001

2.26

1.43–3.65

Age (≥70 years)

< 0.001

< 0.001

2.64

1.81–3.90

PS (2 vs 0–1)

< 0.001

0.026

2.04

1.10–3.56

Smoking

0.002

0.257

NLR (> 1.5)

0.028

0.316

Predicted post PFTa

0.025

0.058

Histology (other vs. adenocarcinoma)

0.034

0.021

1.60

1.07–2.41

Differentiation (m/p vs. well)

< 0.001

0.035

1.64

1.03–2.66

Lymph-vascular invasion

0.002

0.029

1.50

1.04–2.16

Pathological stage (IB vs. IA)

< 0.001

0.006

1.68

1.16–2.45

Postoperative complications

0.024

0.449

Preoperative comorbidities

Hypertension

0.829

Diabetes mellitus

0.496

eGFR (< 70 mL/min/1.73 m2)

0.022

0.890

Child–Pugh classification (B or C)

0.028

0.880

Cardiac disease

0.011

0.301

Cerebral disease

0.014

0.876

Any prior tumors

< 0.001

< 0.001

3.37

2.27–4.96

  1. aPredicted postoperative values of FEV1.0 or DLCO < 40% are defined as high-risk for PFTs
  2. PS performance status, NLR neutrophil-lymphocyte ratio, PFT pulmonary function test, eGFR estimated glomerular filtration rate, m/p moderate or poor