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Table 2 Multivariate analysis of factors predicting overall survival

From: Neutrophil-lymphocyte ratio predicts recurrence in patients with resected stage 1 non-small cell lung cancer

Factors Univariate
(P-value)
Multivariate
(P-value)
Risk ratio 95% CI
Sex (male vs. female) < 0.001 < 0.001 2.26 1.43–3.65
Age (≥70 years) < 0.001 < 0.001 2.64 1.81–3.90
PS (2 vs 0–1) < 0.001 0.026 2.04 1.10–3.56
Smoking 0.002 0.257
NLR (> 1.5) 0.028 0.316
Predicted post PFTa 0.025 0.058
Histology (other vs. adenocarcinoma) 0.034 0.021 1.60 1.07–2.41
Differentiation (m/p vs. well) < 0.001 0.035 1.64 1.03–2.66
Lymph-vascular invasion 0.002 0.029 1.50 1.04–2.16
Pathological stage (IB vs. IA) < 0.001 0.006 1.68 1.16–2.45
Postoperative complications 0.024 0.449
Preoperative comorbidities
Hypertension 0.829
Diabetes mellitus 0.496
eGFR (< 70 mL/min/1.73 m2) 0.022 0.890
Child–Pugh classification (B or C) 0.028 0.880
Cardiac disease 0.011 0.301
Cerebral disease 0.014 0.876
Any prior tumors < 0.001 < 0.001 3.37 2.27–4.96
  1. aPredicted postoperative values of FEV1.0 or DLCO < 40% are defined as high-risk for PFTs
  2. PS performance status, NLR neutrophil-lymphocyte ratio, PFT pulmonary function test, eGFR estimated glomerular filtration rate, m/p moderate or poor