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Table 1 Correlation between HIF-1α, VEGF-A and VEGFR-2

From: The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation

Parameters n VEGF-A (−) (n = 40) VEGF-A (+) (n = 24) χ2 p-value
 HIF-1α (−) 32 30 (20) 2 (12) 26.67 2.41 × 10−7
 HIF-1α (+) 32 10 (20) 22 (12)
Parameters n VEGFR-2 (−) (n = 32) VEGFR-2 (+) (n = 32) χ2 p-value
 HIF-1α (−) 32 22 (16) 10 (16) 9.00 2.70 × 10−3
 HIF-1α (+) 32 10 (16) 22 (16)
Parameters n VEGFR-2 (−) (n = 32) VEGFR-2 (+) (n = 32) χ2 p-value
 VEGF-A (−) 40 26 (20) 14 (20) 9.60 1.95 × 10−3
 VEGF-A (+) 24 6 (12) 18 (12)
  1. All samples are from both side of all recipient lung (the number of allogeneic group is 44 and the number of control group is 20) and divided into two groups based on whether the immunohistochemistry score ≥ 3 of the corresponding protein. (−) represents immunohistochemistry score < 3; (+) represents immunohistochemistry score ≥ 3; HIF-1α Hypoxia inducible factor-1α, VEGF-A Vascular endothelial growth factor-A, VEGFR-2 Vascular endothelial growth factor receptor-2