Table 4 Impact of heparin on coagulation in Propensity-matched Patients
Variable | NS group (n = 148) | Heparin group (n = 148) | P value |
|---|---|---|---|
ACT (second) ** | < 0.05 | ||
At the end of surgery (T0) | 178.9 ± 65.1 | 183.2 ± 66.4 | 0.6 |
At the 6th hour after surgery (T6) | 149.1 ± 45.7 | 160.0 ± 46.6 | 0.04 |
At the 12th hour after surgery (T12) | 146.9 ± 37.0 | 148.7 ± 33.8 | 0.8 |
At the 24th hour after surgery (T24) | 143.7 ± 31.8 | 151.4 ± 31.8 | 0.03 |
At the 48th hour after surgery (T48) | 128.6 ± 29.1 | 138.9 ± 33.7 | < 0.01 |
APTT (second) ** | 0.01 | ||
T0 | 39.2 ± 7.5 | 40.7 ± 11.5 | 0.2 |
T12 | 39.0 ± 9.6 | 38.9 ± 9.4 | 0.9 |
T24 | 36.2 ± 6.8 | 40.1 ± 8.9 | < 0.01 |
T48 | 37.0 ± 8.8 | 39.2 ± 6.9 | < 0.01 |
Allogeneic RBC utilization (U) | 0.1 ± 0.4 | 0.4 ± 1.1 | < 0.05 |
Number of patients (n, %) | 5, 3.4% | 16, 10.8% | < 0.05 |
FFP utilization (ml) | 29.2 ± 111.4 | 26.4 ± 103.4 | 0.8 |
Number of patients (n, %) | 13, 8.8% | 12, 8.1% | 0.9 |
Platelets utilization (U) | 0.5 ± 0.3 | 0.1 ± 0.4 | 0.5 |
Number of patients (n, %) | 3, 2.0% | 5, 3.4% | 0.5 |
Other blood products (n, %) | 2, 1.3% | 6, 4.0% | 0.1 |
Re-operation for bleeding (n, %) | 0 | 1, 0.68% | – |
Drainage of chest tube* from T0 to T48 (ml/kg) | 10.6 ± 9.4 | 13.0 ± 7.2 | < 0.05 |
Number of LMWH used (n, %) | 9, 6.1% | 5, 3.4% | 0.3 |
Protamine utilization from T0 to T24 (mg) | 18.0 ± 11.2 | 21.1 ± 14.3 | < 0.05 |