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Table 4 Impact of heparin on coagulation in Propensity-matched Patients

From: A comparison of heparinised and non-heparinised normal saline solutions for maintaining the patency of arterial pressure measurement cannulae after heart surgery

Variable NS group (n = 148) Heparin group (n = 148) P value
ACT (second) **    < 0.05
 At the end of surgery (T0) 178.9 ± 65.1 183.2 ± 66.4 0.6
 At the 6th hour after surgery (T6) 149.1 ± 45.7 160.0 ± 46.6 0.04
 At the 12th hour after surgery (T12) 146.9 ± 37.0 148.7 ± 33.8 0.8
 At the 24th hour after surgery (T24) 143.7 ± 31.8 151.4 ± 31.8 0.03
 At the 48th hour after surgery (T48) 128.6 ± 29.1 138.9 ± 33.7 < 0.01
APTT (second) **    0.01
 T0 39.2 ± 7.5 40.7 ± 11.5 0.2
 T12 39.0 ± 9.6 38.9 ± 9.4 0.9
 T24 36.2 ± 6.8 40.1 ± 8.9 < 0.01
 T48 37.0 ± 8.8 39.2 ± 6.9 < 0.01
Allogeneic RBC utilization (U) 0.1 ± 0.4 0.4 ± 1.1 < 0.05
Number of patients (n, %) 5, 3.4% 16, 10.8% < 0.05
FFP utilization (ml) 29.2 ± 111.4 26.4 ± 103.4 0.8
Number of patients (n, %) 13, 8.8% 12, 8.1% 0.9
Platelets utilization (U) 0.5 ± 0.3 0.1 ± 0.4 0.5
Number of patients (n, %) 3, 2.0% 5, 3.4% 0.5
Other blood products (n, %) 2, 1.3% 6, 4.0% 0.1
Re-operation for bleeding (n, %) 0 1, 0.68%
Drainage of chest tube* from T0 to T48 (ml/kg) 10.6 ± 9.4 13.0 ± 7.2 < 0.05
Number of LMWH used (n, %) 9, 6.1% 5, 3.4% 0.3
Protamine utilization from T0 to T24 (mg) 18.0 ± 11.2 21.1 ± 14.3 < 0.05
  1. Mean ± SD, RBC: Red Blood Cell, NS: Normal Saline, PT: Prothrombin time, APTT: Activated Partial Thromboplastin Time, ACT: Activated Clotting Time, FFP: Fresh Frozen Plasma, LMWH: Low Molecular Weight Heparin, *: chest tube is placed in pleural cavity, pericardial cavity and mediastinal, **: P value was adjusted by Bonferroni correction