Table 2 Patient characteristics according to TDT (< 400 and ≥ 400) in pathological stages IA1, IA2, IA3 and IB (n = 176)
From: Solid component tumor doubling time is a prognostic factor in non-small cell lung cancer patients
Stage IA1 (n = 49) | Stage IA2 (n = 61) | Stage IA3 (n = 20) | Stage IB (n = 46) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
TDT < 400 | TDT ≥ 400 | TDT < 400 | TDT ≥ 400 | TDT < 400 | TDT ≥ 400 | TDT < 400 | TDT ≥ 400 | |||||
n = 17 | n = 32 | p-value | n = 34 | n = 27 | p-value | n = 13 | n = 7 | p-value | n = 31 | n = 15 | p-value | |
Age (mean ± SD) | 73.9 ± 7.8 | 68.1 ± 8.3 | 0.02 | 69.4 ± 10.9 | 66.5 ± 10.1 | 0.299 | 75.4 ± 5.2 | 63.3 ± 11.1 | 0.03 | 72.3 ± 7.6 | 72.5 ± 9.6 | 0.966 |
Sex (Male/Female) | 6 (35.3%)/11 (64.7%) | 11 (34.4%)/21 (65.6%) | 0.949 | 26 (76.5%)/8 (23.5%) | 13 (48.1%)/14 (51.9%) | 0.022 | 10 (76.9%)/3 (23.1%) | 4 (57.1%)/3 (42.9%) | 0.357 | 24 (77.4%)/7 (22.6%) | 11 (73.3%)/4 (26.7%) | 0.761 |
Smoking History (Never/Ever) | 5 (29.4%)/12 (70.6%) | 8 (25%)/24 (75%) | 0.739 | 22 (64.7%)/12 (35.3%) | 11 (40.7%)/16 (59.3%) | 0.062 | 10 (76.9%)/3 (23.1%) | 4 (57.1%)/3 (42.9%) | 0.357 | 26 (83.9%)/5 (16.1%) | 10 (66.7%)/5 (33.3%) | 0.257 |
Serum CEA (mean ± SD) | 2.2 ± 1.1 | 2.8 ± 3.1 | 0.488 | 2.6 ± 1.8 | 3.2 ± 1.7 | 0.223 | 10.7 ± 24.4 | 2.8 ± 1.1 | 0.408 | 4.2 ± 3.0 | 9.3 ± 20.0 | 0.172 |
Type of resection | ||||||||||||
Segmentectomy | 6 (35.3%) | 8 (25%) | 0.448 | 5 (14.7%) | 3 (11.1%) | 0.68 | 0 | 0 | – | 0 | 1 (6.7%) | 0.326 |
Lobectomy | 11 (64.7%) | 24 (75%) | 29 (85.3%) | 24 (88.9%) | 13 (100%) | 7 (100%) | 31 (100%) | 14 (93.3%) | ||||
Pneumonectomy | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
Histological type | ||||||||||||
Adenocarcinoma | 16 (94.1%) | 31 (96.9%) | 0.578 | 21 (61.8%) | 25 (92.6%) | 0.021 | 7 (53.8%) | 6 (85.7%) | 0.319 | 18 (58.1%) | 10 (66.7%) | 0.802 |
Squamous cell carcinoma | 1 (5.9%) | 0 | 7 (20.6%) | 1 (3.7%) | 4 (30.7%) | 1 (14.3%) | 9 (29%) | 3 (20%) | ||||
Others | 0 | 1 (3.1%) | 6 (17.6%) | 1 (3.7%) | 2 (15.4%) | 0 | 4 (12.9%) | 2 (13.3%) | ||||
Solid component | ||||||||||||
Pure solid/mixed GGO | 10/7 | 11/22 | 0.084 | 19/15 | 11/16 | 0.24 | 6/7 | 2/5 | 0.44 | 10/21 | 5/10 | 0.94 |