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Table 5 COX regression analysis for long-term mortality

From: Characteristics and outcomes of Stanford type A aortic dissection patients with severe post-operation hyperbilirubinemia: a retrospective cohort study

Characteristic Univariate COX regression Multivariate COX regression
OR (95%CI) P value OR (95%CI) P value
Age 1.023 (1.003–1.043) 0.026   
Preoperative
 SCr 1.006 (1.002–1.010) < 0.001   
 APACHE II score 1.122 (1.060–1.188) < 0.001   
 MELD score 1.052 (1.003–1.105) 0.039   
Intraoperative
 Operation duration 1.248 (1.098–1.414) 0.001   
 CPB time 1.005 (1.002–1.008) 0.001   
Postoperative
 MAP 0.971 (0.957–0.985) < 0.001 0.979 (0.962–0.995) 0.012
 The total amount of blood transfusion 1.009 (1.007–1.011) < 0.001   
 Mechanical ventilation time 1.035 (1.020–1.051) < 0.001   
 AKI (yes/no) 6.25 (2.295–17.024) < 0.001   
 Stage of AKI   < 0.001   < 0.001
  Stage 1 1.404 (0.506–3.901) 0.515 1.037 (0.365–2.946) 0.946
  Stage 2 2.772 (0.929–8.271) 0.068 2.236 (0.774–6.990) 0.133
  Stage 3 15.071 (6.043–37.587) < 0.001 12.604 (5.002–31.762) < 0.001
 Use of CRRT (yes/no) 6.368 (4.174–9.709) < 0.001   
 Use of PE/BA (yes/no) 3.184 (1.596–6.351) 0.001   
 Use of ECMO (yes/no) 6.108 (2.638–14.139) < 0.001 12.167 (4.588–32.264) < 0.001
 Onset of hyperbilirubinemia 1.217 (1.044–1.418) 0.012   
 Peak TB concentration 1.004 (1.003–1.006) < 0.001   
 Peak TB > 121 μmol/l (yes/no) 2.595 (1.679–4.001) < 0.001   
 Peak TB > 171 μmol/l (yes/no) 2.292 (1.488–3.530) < 0.001   
 Time to peak TB concentration 1.156 (1.107–1.208) < 0.001   
ICU stay time 1.037 (1.022–1.053) < 0.001   
  1. ACC Aortic cross clamp, AKI Acute kidney injury, APACHEII Acute physiology and chronic health evaluation II, BA Bilirubin adsorption, CPB Cardiopulmonary bypass, CRRT Continuous renal replacement therapy, ECMO Extracorporeal membrane oxygenation, ICU Intensive care unit, MAP Mean arterial pressure, MELD Model for end-stage liver disease, PE Plasma exchange, SCr Serum creatinine, TB Total bilirubin