Characteristics and outcomes of Stanford type A aortic dissection patients with severe post-operation hyperbilirubinemia: a retrospective cohort study

Table 5 COX regression analysis for long-term mortality

Characteristic	Univariate COX regression		Multivariate COX regression
Characteristic	OR (95%CI)	P value	OR (95%CI)	P value
Age	1.023 (1.003–1.043)	0.026
Preoperative
SCr	1.006 (1.002–1.010)	< 0.001
APACHE II score	1.122 (1.060–1.188)	< 0.001
MELD score	1.052 (1.003–1.105)	0.039
Intraoperative
Operation duration	1.248 (1.098–1.414)	0.001
CPB time	1.005 (1.002–1.008)	0.001
Postoperative
MAP	0.971 (0.957–0.985)	< 0.001	0.979 (0.962–0.995)	0.012
The total amount of blood transfusion	1.009 (1.007–1.011)	< 0.001
Mechanical ventilation time	1.035 (1.020–1.051)	< 0.001
AKI (yes/no)	6.25 (2.295–17.024)	< 0.001
Stage of AKI		< 0.001		< 0.001
Stage 1	1.404 (0.506–3.901)	0.515	1.037 (0.365–2.946)	0.946
Stage 2	2.772 (0.929–8.271)	0.068	2.236 (0.774–6.990)	0.133
Stage 3	15.071 (6.043–37.587)	< 0.001	12.604 (5.002–31.762)	< 0.001
Use of CRRT (yes/no)	6.368 (4.174–9.709)	< 0.001
Use of PE/BA (yes/no)	3.184 (1.596–6.351)	0.001
Use of ECMO (yes/no)	6.108 (2.638–14.139)	< 0.001	12.167 (4.588–32.264)	< 0.001
Onset of hyperbilirubinemia	1.217 (1.044–1.418)	0.012
Peak TB concentration	1.004 (1.003–1.006)	< 0.001
Peak TB > 121 μmol/l (yes/no)	2.595 (1.679–4.001)	< 0.001
Peak TB > 171 μmol/l (yes/no)	2.292 (1.488–3.530)	< 0.001
Time to peak TB concentration	1.156 (1.107–1.208)	< 0.001
ICU stay time	1.037 (1.022–1.053)	< 0.001

ACC Aortic cross clamp, AKI Acute kidney injury, APACHEII Acute physiology and chronic health evaluation II, BA Bilirubin adsorption, CPB Cardiopulmonary bypass, CRRT Continuous renal replacement therapy, ECMO Extracorporeal membrane oxygenation, ICU Intensive care unit, MAP Mean arterial pressure, MELD Model for end-stage liver disease, PE Plasma exchange, SCr Serum creatinine, TB Total bilirubin

ISSN: 1749-8090