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Table 1 Baseline Characteristics of Patients

From: Comparison of different bridging anticoagulation therapies used after mechanical heart valve replacement in Chinese patients - a prospective cohort study

Characteristic

the UFH group (n = 109)

the UFH-LMWH group (n = 99)

the LMWH group (n = 97)

P Value

Male, n (%)

63 (57.8%)

63 (63.6%)

51 (52.6%)

0.29

Age, years

50.3 ± 10.6

49.7 ± 11.1

52.4 ± 10.2

0.19

Weight, kg

63.1 ± 9.8

63.5 ± 10.3

64.4 ± 10.0

0.66

BMI, kg/m2 a

22.6 ± 3.0

22.3 ± 3.2

23.1 ± 2.7

0.17

LVEF, %

57.1 ± 5.8

55.7 ± 7.0

56.3 ± 6.4

0.23

CHA2DS2-VASc-Score

1.5 ± 0.9

1.5 ± 0.9

1.7 ± 1.0

0.12

NYHAb class III or IV, n (%)

75 (68.8%)

65 (65.7%)

67 (69.1%)

0.85

Current smoker, n (%)

21 (19.3%)

24 (24.2%)

20 (20.6%)

0.67

Hypertension, n (%)

13 (11.9%)

16 (16.2%)

20 (20.6%)

0.24

Diabetes, n (%)

2 (1.8%)

3 (3.0%)

2 (2.1%)

0.83

Atrial fibrillation, n (%)c

34 (31.2%)

23 (28.9%)

32 (33.0%)

0.27

Coronary artery disease, n (%)

5 (4.6%)

8 (8.1%)

10 (10.3%)

0.29

Pulmonary hypertension, n (%)

17 (15.6%)

17 (17.2%)

15 (15.5%)

0.94

Infective endocarditis, n (%)

4 (3.7%)

4 (4.0%)

2 (2.1%)

0.71

History of aspirin, n (%)

4 (3.7%)

7 (7.1%)

8 (8.2%)

0.36

Previous cardiovascular surgery, n (%)

0 (0.0%)

1 (1.0%)

0 (0.0%)

0.35

Previous embolism, n (%)

5 (4.6%)

3 (3.0%)

4 (4.1%)

0.84

Previous bleeding, n (%)

3 (2.8%)

5 (5.1%)

3 (3.1%)

0.64

Biologic data

 Hemoglobin, g/L

143.2 ± 19.7

145.6 ± 23.0

141.1 ± 18.7

0.32

 Platelet count, 109/L

173.5 ± 69.0

171.4 ± 51.3

180.1 ± 66.0

0.60

 Albumin, g/L

42.9 ± 3.7

42.4 ± 3.8

43.3 ± 3.2

0.20

 Creatinine, μmol/L

71.4 ± 11.2

75.1 ± 20.7

76.7 ± 15.5

0.06

 Triglycerides, mmol/L

1.2 ± 0.6

1.4 ± 0.9

1.3 ± 0.6

0.41

 LDL-C, mmol/Ld

2.5 ± 0.8

2.6 ± 0.9

2.6 ± 0.9

0.82

 Prothrombin time, sec

12.7 ± 3.8

12.5 ± 3.5

12.4 ± 2.8

0.34

 Fibrinogen, g/L

3.0 ± 0.8

2.9 ± 0.8

3.0 ± 0.9

0.76

Operative Characteristics

 AVR e

33 (30.3%)

33 (33.3%)

29 (29.9%)

0.85

 MVR f

37 (33.9%)

25 (25.3%)

32 (33.0%)

0.34

 BVR g

22 (20.2%)

20 (20.2%)

21 (21.6%)

0.96

 Bentall h

17 (15.6%)

21 (21.2%)

15 (15.5%)

0.47

 Cross-clamp time, minutes

82.8 ± 35.1

83.4 ± 36.1

82.6 ± 29.4

0.98

 Total bypass time, minutes

121.6 ± 44.0

117.1 ± 43.0

117.0 ± 37.6

0.67

  1. Continuous variables are expressed as mean ± SD; categorical variables are expressed as number (percentage)
  2. aBody mass index (kg/m2); bNew York Heart Association functional class;
  3. cIncludes transient, persistent, permanent atrial fibrillation; dLow density lipoprotein cholesterin
  4. eAortic valve replacement; fMitral valve replacement; gBivalve replacement
  5. hAortic valve replacement +ascending aorta replacement