Table 1 The oncological results in the 7 included studies (vein-first versus artery-first)
From: Vein-first versus artery-first ligation procedure for lung cancer surgery: An updated review
References | Country | Study design | Level of evidence* | No. of patients | Tumor staging | Local recurrence | Distant metastasis | 5-year DFS | 5-year OS | HR (95% CI) of the sequence for survival | Comments |
|---|---|---|---|---|---|---|---|---|---|---|---|
Kozak [10] | Poland | Single-center RCT | 2 | 170/215 | I–III, p > 0.05 | NR | Total: 69 (17.9%) | NR | 92 (54%) vs. 108 (50%), p > 0.05 | OS: 0.927 (0.708–1.214) (artery-first as reference) | – |
Bai [11] | China | Single-center RCT | 3 | 45/45 | I: 39/38; II: 6/7, p > 0.05 | 3 (6.7%) vs. 2 (4.4%), p > 0.05 | 8 (17.8%) vs. 6 (13.3%), p > 0.05 | 29.5 months vs. 28.3 months, p > 0.05 | NR | OS: 0.154 (0.251–0.852) (artery-first as reference) | – |
Refaely [12] | Israel | Retrospective | 4 | 133/146 | I: 77/75; II: 21/29; III: 29/39; IV: 6/3, p > 0.05 | 68 (51%) vs. 78 (53%), p > 0.05 | NR | NR | NR | Not significant | – |
Li [13] | China | Retrospective | 4 | 174/93 | I: 138/79; II: 36/14, p > 0.05 | 6 (3.4%) vs. 2 (2.2%), p > 0.05 | 22 (12.6%) vs. 7 (7.5%), p > 0.05 | Not significant | Not significant | Not significant | – |
Sumitomo [5] | Japan | Retrospective | 4 | 104/83 | I: 91/70; II: 5/8; IIIA: 8/5, p > 0.05 | 4 (3.8%) vs. 6 (7.2%), p > 0.05 | 3 (2.9%) vs. 9 (10.8%), p < 0.05 | 92 (88.2%) vs. 63 (75.7%), p < 0.05 | 94 (90.9%) vs. 69 (82.7%), p > 0.05 | DFS: 2.127 (1.009–4.481) (vein-first as reference) | DFS of stage I (91 vs. 70), p < 0.05; DFS of stage II - IIIA (13 vs. 13), p > 0.05 |
He [14] | China | Retrospective | 4 | 33/27 | I: 14/10; II: 8/9; III: 10/8; IVA: 1/0, p > 0.05 | NR | NR | 13 (39.40%) vs. 8 (29.6%), p > 0.05 | 22 (66.7%) vs. 12 (44.4%), p > 0.05 | - | OS/PFS of squamous type (10 vs. 8), p < 0.05 |
Wei [4] | China | Retrospective PSM | 4 | 210/210 | I–II | NR | NR | 134 (63.6%) vs. 102 (48.4%), p < 0.05 | 155 (73.6%) vs. 121 (57.6%), p < 0.05 | OS: 1.65 (1.07–2.56) (vein-first as reference) | Vein-first better survival in stage I/ II |