Transcatheter mitral valve replacement for degenerated mitral valve bioprostheses, failure of mitral valvuloplasty and native valve with severe mitral annulus calcification: a systematic review and meta-analysis

You, Tao; Wang, Wei; Yi, Kang; Gao, Jie; Zhang, Xin; He, Shao-E.; Xu, Xiao-Min; Ma, Yu-Hu; Li, Xin-Yao

doi:10.1186/s13019-021-01677-7

Table 3 Baseline comparability analysis results (ViV vsViR)

From: Transcatheter mitral valve replacement for degenerated mitral valve bioprostheses, failure of mitral valvuloplasty and native valve with severe mitral annulus calcification: a systematic review and meta-analysis

Baseline	Studies	Effect measure	Model	Participants	Effect estimate	LCI	UCI	Q	P(Q)	Z	P(Z)
Age (years)	4	Mean difference	Fixed	1862	2.48	1.23	3.72	3.93	0.27	3.90	*< 0.01*
Female	5	Odds ratio	Fixed	2665	1.73	1.44	2.10	4.82	0.31	5.70	*< 0.01*
Diabetes mellitus	5	Odds Ratio	Fixed	2599	0.85	0.69	1.07	4.20	0.38	1.40	0.16
Hypertension	2	Odds ratio	Fixed	538	1.10	0.73	1.65	0.91	0.34	0.45	0.65
Atrial fibrillation	4	Odds ratio	Fixed	2136	1.47	1.18	1.84	3.83	0.28	3.45	*< 0.01*
Chronic kidney disease	3	Odds ratio	Random	2061	0.80	0.54	1.17	4.71	0.09	1.16	0.25
Severe/chronic lung disease	5	Odds ratio	Fixed	2599	1.00	0.81	1.24	2.70	0.61	0.01	0.99
Peripheral arterial disease	3	Odds ratio	Fixed	1353	0.84	0.60	1.18	0.41	0.82	1.01	0.31
Prior cerebrovascular accident	4	Odds ratio	Fixed	2420	1.59	1.19	2.13	0.57	0.90	3.12	*< 0.01*
Prior percutaneous coronary intervention	1	Odds ratio	Fixed	463	0.63	0.38	1.03	0.00	1.00	1.85	0.06
Prior pacemaker	2	Odds ratio	Random	1879	0.76	0.29	2.03	13.03	0.00	0.54	0.59
Prior aortic valve replacement	2
TAVR	1	Odds ratio	Fixed	788	1.18	0.26	5.31	0.00	1.00	0.22	0.83
SAVR	2	Odds ratio	Fixed	960	1.15	0.74	1.78	0.00	0.99	0.62	0.54
STS risk score (%)	3	Mean difference	Random	630	4.88	− 1.65	11.40	22.13	0.00	1.47	0.14
Creatinine	2	Std. mean difference	Fixed	538	− 0.19	− 0.38	− 0.01	1.05	0.30	2.02	*0.04*
Hemoglobin (g/dl)	1	Mean difference	Fixed	75	0.60	− 0.84	2.04	0.00	1.00	0.82	0.41
NT-proBNP (ng/l)	1	Mean difference	Fixed	75	1006	− 1190	3202	0.00	1.00	0.90	0.37
Echocardiographic parameters	4
LVEF, left ventricular ejection fraction (%)	4	Mean difference	Random	1862	11.01	9.49	12.53	4.68	0.20	14.17	*< 0.01*
Right ventricular systolic pressure (mm Hg)	1	Mean difference	Random	75	6.00	− 6.32	18.32	0.00	1.00	0.95	0.34
Mitral valve mean gradient (mmHg)	3	Mean difference	Random	1787	4.14	3.25	5.03	4.33	0.11	9.09	*< 0.01*
PASP (mmHg)	1	Mean difference	Random	1079	2.70	0.08	5.32	0.00	1.00	2.02	*0.04*
MVA, mitral valve area (cm²)	1	Mean difference	Random	1079	− 0.46	− 0.61	− 0.31	0.00	1.00	5.86	*< 0.01*
Mode of prosthesis failure	5
Regurgitation	5	Odds ratio	Random	2630	0.25	0.16	0.40	10.17	0.04	5.89	*< 0.01*
Stenosis	5	Odds ratio	Random	2630	2.69	1.50	4.80	19.27	0.00	3.34	*< 0.01*
Combined	4	Odds ratio	Fixed	1827	1.56	1.22	1.99	1.82	0.61	3.52	*< 0.01*
NYHA	5
I/II	2	Odds ratio	Random	1882	1.30	0.43	3.92	6.32	0.01	0.46	0.64
III/IV	5	Odds ratio	Random	2588	1.31	0.25	6.78	22.37	0.00	0.32	0.75

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