Fig. 3

Upregulation of miR-499a-5p reduced the myocardial dysfunction in sepsis. AC16 cells were transfected with mimic-NC or miR-499a-5p-mimic, followed by LPS treatment. a The expression of miR-499a-5p was detected by RT-qPCR; b CCK-8 assay was used to detect cell viability; c the expression of CK-MB, BNP, SOD and COX IV were detected by ELISA; Three independent repeated tests were carried out, and the data were depicted as mean ± SD. One-way ANOVA was used for data analysis in panels a/c, two-way ANOVA was used for data analysis in panel b, and Tukey's post hoc test was used for post hoc test. *P < 0.05