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Table 1 Characteristics of Included Studies

From: The prognostic significance of postoperative hyperbilirubinemia in cardiac surgery: systematic review and meta-analysis

Study ID Study Design Sample Size (N) Case mix PH incidence % (n) % Male and age (mean (SD)) Bilirubin threshold (mg/dL) Minimum monitoring period (days) Number of units of blood transfused in PH group (mean (SD)) Number of units of blood transfused in non-PH group (mean (SD)) CPB Time (mins) Cross Clamp time (mins) Outcomes reported
Collins [24] Prospective (single centre) N = 248 20% (50) NR 3 7 10.1 (7.5) 5.3 (3.5) 91.96 NR In-hospital mortality
7% TV
60% MV
39% AV
38% CABG
Wang [33] Prospective (single centre) N = 302 35% (106) 57% Male 3 7 NR NR 121.2 70.3 In-hospital mortality
30% CABG 51.87 (0.8) ICU LOS
32% Valve
24% Redo
6% CHD
7% Complex
Chandra [34] Prospective (single centre) N = 77 26% (20) 70% Male 2 7 NR NR 93.5 46.3 In-hospital mortality
26% CABG 32.1% (16.4) ICU LOS
38% first time valve Hospital LOS
4% valve reoperation
27% congenital repair
50% reconstructive procedure
Hosotsubo [27] Retrospective (single centre) N = 133 51% (68) 59% Male 2 14 6.85 (0.88) 4.0 (0.52) NR NR In-hospital mortality
38% CABG 60 (1.3) ICU LOS
48% valvular
14% Aneurysm
An [23] Prospective N = 386 25% (96) 47% Male 3 7 3.56 (0.02) 2.15 (0.03) 116.8 70.6 In-hospital mortality
(single centre) 57% valve cases 46.3 (1.14) ICU LOS
36% CHD cases Ventilation Time
4% combined cases
0% CABG
Leacche [29] Retrospective (single centre) N = 136 NR 37% Male 2 5 NR NR 154 99 In-hospital mortality
40% CABG/valve 67(12)
29% CABG only
15% valve only
9% transplant
Kraev [28] Retrospective (single centre) N = 826 9% (74) 71% Male 2.8 7 8.0 (10.0) 2.49 (2.77) 143 106 In-hospital mortality
62% CABG 65 (13) Hospital LOS
6% Valve Long-term Mortality
32% other  
Vidal [32] Prospective N = 73 23% (16) 68% Male 3 NR NR NR 106 65 In-hospital mortality
(single centre) 23% valve replacement 71 (11)
22% CABG
52% Combined
3% Other
Nishi [30] Prospective N = 334 19% (63.46) 60% Male 3 7 NR NR 183 NR In-hospital mortality
(single centre) 49% aortic valve 64.3 (14.9)
51% mitral valve
22% tricuspid
0% CABG
Sharma [31] Prospective N = 476 25% (119) NR 2 7 3.95 (0.68) 2.29 (0.67) 103.77 74.06 In-hospital mortality
(single centre) 42% CABG ICU LOS
34% valve repair Hospital LOS
17% congenital Ventilation Time
6% Valve + CABG
Diab [25] Retrospective N = 285 25% (71) 71% Male 3 2 NR NR 135 NR In-hospital mortality
(single centre) 44% single aortic valve IE 62 (14.1) Long-term mortality
28% single mitral valve IE
27% both valves
21% prosthetic valve IE
0% CABG
Golitaleb [26] Prospective (single centre) N = 600 25% (150) 55% Male 3 7 NR NR 105 81.67 In-hospital mortality
33% CABG 63.8 (8.94) ICU LOS
33% AVR + CABG Hospital LOS
33% MVR + CABG
  1. AV aortic valve, AVR aortic valve replacement, CABG coronary artery bypass grafts, CHD congenital heart disease, IE infective endocarditis, MV mitral valve, MVR mitral valve replacement, NR Not reported, TV tricuspid