Table 3 Univariate analysis and multivariable regression analysis for the factors associated with the development of major adverse events
Major adverse events | ||||||
|---|---|---|---|---|---|---|
Univariate analysis | p value | |||||
Sex | Female | 51 | 52.0 | 9 | 31.0 | 0.047* |
Male | 47 | 48.0 | 20 | 69.0 | ||
Age at operation | Median (IQR) | 8.0 (6.0–10.0) | 9.0 (7.0–14.0) | 0.020* | ||
Weight at operation | Median (IQR) | 5.5 (4.7–6.8) | 6.0 (5.3–8.0) | 0.045* | ||
Down Syndrome | No | 70 | 71.4 | 18 | 62.1 | 0.337 |
Yes | 28 | 28.6 | 11 | 37.9 | ||
Type of VSD | Others | 12 | 12.2 | 4 | 13.8 | 0.682 |
Inlet | 36 | 36.7 | 8 | 27.6 | ||
Outlet | 23 | 23.5 | 7 | 24.1 | ||
PM | 23 | 23.5 | 7 | 24.1 | ||
Multiple | 4 | 4.1 | 3 | 10.3 | ||
Associated CHD | No | 44 | 44.9 | 8 | 27.6 | 0.132 |
Yes | 54 | 55.1 | 21 | 72.4 | ||
Right ventricular hypertrophy | No | 88 | 89.8 | 13 | 44.8 | < 0.001* |
Yes | 10 | 10.2 | 16 | 55.2 | ||
Pulmonary artery banding | No | 89 | 90.8 | 12 | 41.4 | < 0.001* |
Yes | 9 | 9.2 | 17 | 58.6 | ||
VSD Repair | Interrupted | 51 | 52.0 | 20 | 69.0 | 0.107 |
Continuous | 47 | 48.0 | 9 | 31.0 | ||
Significant intraoperative Residual VSD | No | 93 | 94.9 | 20 | 69.0 | < 0.001* |
Yes | 5 | 5.1 | 9 | 31.0 | ||
Cross clamp time (Minutes) | Median (IQR) | 59.5 (49.0–70.0) | 69.0 (49.0–85.0) | 0.086 | ||
Total CPB time (Minutes) | Median (IQR) | 83.0 (70.0–93.0) | 102.0 (77.0–140.0) | 0.006* | ||
Multivariable logistic regression analysis | ||||
|---|---|---|---|---|
Risk factors | Beta coefficient | p value | Odds ratio | 95% CI Odds ratio |
Sex (male) | 1.223 | 0.034* | 3.398 | 1.098–10.516 |
Pulmonary artery banding | 2.659 | < 0.001* | 14.282 | 4.722–43.195 |
Significant intraoperative (3 mm) residual VSD | 2.156 | 0.003* | 8.634 | 2.130–35.001 |