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Table 3 Postoperative outcomes according to the study groups

From: Impact of hyperbilirubinemia associated acute kidney injury on chronic kidney disease after aortic arch surgery: a retrospective study with follow-up of 1-year

Variable

Non-AKI group (n = 97)

AKI without HB group (n = 119)

HB-AKI group (n = 68)

P

Sepsis

2 (2.1%)

6 (5.0%)

7 (10.3%)

0.071

Re-exploration for bleeding

5 (5.2%)

12 (10.1%)

4 (5.9%)

0.400

CRRT

0 (0)

58 (48.7%)

41 (60.3%)

< 0.001

Tracheotomy

7 (7.2%)

25 (21.0%)

16 (23.5%)

0.004

ECMO

0 (0)

2 (1.7%)

0 (0)

0.511

Stroke

1 (1.0%)

4 (3.4%)

4 (5.9%)

0.209

AKI class

   

< 0.001

AKI1

0 (0)

26 (21.8%)

6 (8.8%)

 

AKI2

0 (0)

27 (22.7%)

10 (14.7%)

 

AKI3

0 (0)

66 (55.5%)

52 (76.5%)

 

Postoperative laboratory characteristics

Peak AST, IU/L

60.0 (40.9–92.0)

92.0 (56.0–213.0)

189.5 (71.0–545)

0.011

Peak ALT, IU/L

42.0 (29.3–77.5)

67.0 (35.0–124.1)

119.9 (45.0–428.5)

0.022

Peak total bilirubin, μmol/L

38.7 (25.8–51.2)

31.9 (24.8–43.0)

69.9 (59.0–98.8)

< 0.001

Peak sCr, μmol/L

101.0 (86.6–130.0)

204.0 (135.3–358.9)

253.8 (176.8–329.7)

< 0.001

Peak BUN, μmol/L

13.2 (10.8–16.5)

19.2 (15.0–26.2)

20.8 (14.3–30.2)

< 0.001

30-day death

4 (4.1%)

10 (8.4%)

11 (16.2%)

0.024

Mechanical ventilation time, h

24.0 (20.0–60.0)

72.0 (24.0–144.0)

72.5 (48.0–187.5)

< 0.001

Hospital stay, d

23.0 (19.0–32.0)

25.5 (20.0–38.0)

28.0 (17.0–44.0)

0.049

CKD

6 (6.2%)

21 (17.6%)

19 (27.9%)

0.001

  1. AKI acute kidney injury; HB hyperbilirubinemia; CRRT continuous renal replacement therapy; ECMO extracorporeal membrane oxygenation; AKI1 1.5–1.9 times baseline sCr; AKI2 2.0–1.9 times baseline sCr; AKI3 3 times baseline or initiation of CRRT; AST aspartate transaminase; ALT alanine aminotransferase; sCr serum creatinine; BUN blood urea nitrogen; CKD chronic kidney disease