RNA methylation in vascular disease: a systematic review

Table 3 Association between m6A methylation and vascular diseases

Vascular diseases	m6A-related molecules	Expression	m6A levels	Main function	Reference
Coronary heart disease	METTL14	Upregulated	Increased	Aggravates vascular calcification	[80]
	FTO	Upregulated	Reduced	Decreases m6A modification of SERCA2a, MY617, and RY2, reducing fibrosis in infarcted areas	[70]
	FTO rs9939609 variant	–	–	Regulates CHD morbidity	[70]
	SNP rs12286 (ADAMTS7)	–	–	Affects RNA m6A modification	[81]
Stroke	FTO	Downregulated	Increased	Modulates poststroke biological processes (inflammation, apoptosis, and transcriptional regulation)	[83]
Aortic aneurysm	FTO	Downregulated	Increased	Induces the formation of aneurysmal smooth muscle cells, macrophage infiltration, and neovascularization	[84]
Aortic aneurysm	METTL14 and YTHDF3	Upregulated	Increased	Induces aneurysmal smooth muscle cell formation, macrophage infiltration, and neovascularization	[84]
Aortic Dissection	METTL3	Upregulated	Increased	Affects hypoxia stress, inducing the differentiation of adipose-derived stem cells into smooth muscle cells Regulates macrophage differentiation and T cells number and function	[86 87
	WTAP	Upregulated	Increased	Participates in a protein complex that affects smooth muscle cell and endothelial cell proliferation and apoptosis	[89]
	HNRNPA2/B1	Upregulated	–	Affects smooth muscle cell differentiation, increasing systolic type smooth muscle cells	[90]
	YTHDF2	Downregulated	–	Decreases inflammation and increases vascular reconstruction and metastatic progression	[91]

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