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Table 1 Baseline characteristics of the study population

From: S100B predicts neurological injury and 30-day mortality following surgery for acute type A aortic dissection: an observational cohort study

Baseline data

All patients n = 393

Neurological Injury *

n = 94

No Neurological Injury *

n = 296

p

Missing

Age (years)

64.4 ± 11.1

65.5 ± 10.1

64.0 ± 11.5

0.26

0 (0)

Female

135 (34.4)

28 (29.8)

107 (36.1)

0.26

0 (0)

Hypertension

208 (52.9)

54 (57.4)

152 (51.4)

0.30

0 (0)

Diabetes Mellitus

80 (20.4)

27 (28.7)

52 (17.6)

0.02

0 (0)

COPD

26 (6.6)

4 (4.3)

21 (7.1)

0.33

0 (0)

Smoking

133 (35.5)

35 (40.2)

97 (34.0)

0.29

18 (4.6)

Coronary artery disease

24 (7.0)

5 (5.8)

19 (7.5)

0.60

50 (12.7)

Known thoracic aneurysm

37 (10.8)

7 (8.2)

30 (11.8)

0.36

51 (13.0)

Marfan syndrome

22 (5.6)

4 (4.3)

18 (6.1)

0.50

0 (0)

Other connective tissue disease

5 (1.3)

1 (1.2)

4 (1.6)

1.00

50 (12.7)

Family history of dissection

16 (4.1)

3 (3.2)

13 (4.4)

0.77

0 (0)

Previous cardiac surgery

7 (1.8)

2 (2.1)

5 (1.7)

0.68

1 (0.3)

Previous Aortic Surgery

12 (3.1)

2 (2.1)

10 (3.4)

0.74

1 (0.3)

Syncope

61 (17.8)

21 (24.4)

39 (15.4)

0.06

50 (12.7)

Hypotensive shock

81 (24.0)

26 (30.6)

54 (21.6)

0.01

55 (14.0)

Preoperative cardiac arrest

16 (4.7)

6 (7.0)

10 (3.9)

0.25

50 (12.7)

Cardiac tamponade

49 (14.3)

18 (20.9)

30 (11.8)

0.04

50 (12.7)

Any malperfusion

142 (36.1)

45 (47.9)

95 (32.1)

< 0.01

0 (0)

Cerebral malperfusion

58 (14.8)

27 (28.7)

31 (10.5)

< 0.01

1 (0.3)

Carotid Dissection

   

0.26

26 (6.6)

None

Unilateral

Bilateral

185 (50.4)

73 (19.9)

109 (29.7)

38 (42.7)

21 (23.6)

30 (33.7)

145 (52.7)

52 (18.9)

78 (28.4)

  

Intramural hematoma

51 (14.9)

10 (11.6)

41 (16.2)

0.31

51 (13.0)

Debakey type 1

300 (76.7)

71 (76.3)

226 (76.6)

0.96

2 (0.5)

Preoperative Creatinine (μmol/l)

89 (73–110)

93.5 (77–125)

87 (72–106)

< 0.01

8 (2.0)

S100B T0 (μg/l)

0.27 (0.06–0.89)

0.27 (0.11–0.93)

0.21 (0.05–0.89)

0.41

330 (84.0)

  1. *Patients who died intraoperatively (n = 3) were excluded from analysis
  2. Values are presented as n (%), mean ± SD or median (interquartile range)
  3. p-values represent comparison between neurological injury group and no neurological injury group
  4. T0 Preoperative, COPD Chronic obstructive pulmonary disease