Table 1 Baseline characteristics of subjects in the original and matched cohorts
Covariates | Original cohort | Matched cohort | ||||
|---|---|---|---|---|---|---|
Normal fibrinogen group | High fibrinogen group | SMD | Normal fibrinogen group | High fibrinogen group | SMD | |
N | 344 | 289 | 222 | 222 | ||
Age (years) | 64.63 ± 8.84 | 64.70 ± 9.09 | 0.008 | 64.64 ± 9.40 | 65.22 ± 8.87 | 0.064 |
Men (%) | 271 (78.8) | 212 (73.4) | 0.127 | 167 (75.2) | 167 (75.2) | < 0.001 |
Smoking (%) | 120 (34.9) | 107 (37.0) | 0.045 | 82 (36.9) | 78 (35.1) | 0.038 |
Family history of CHD (%) | 7 ( 2.0) | 8 ( 2.8) | 0.048 | 6 ( 2.7) | 5 ( 2.3) | 0.029 |
Hypertension (%) | 225 (65.4) | 189 (65.4) | < 0.001 | 143 (64.4) | 142 (64.0) | 0.009 |
Hyperlipidemia (%) | 93 (27.0) | 84 (29.1) | 0.045 | 66 (29.7) | 60 (27.0) | 0.06 |
Diabetes (%) | 100 (29.1) | 92 (31.8) | 0.06 | 59 (26.6) | 68 (30.6) | 0.09 |
Unstable angina (%) | 68 (19.8) | 81 (28.0) | 0.195 | 58 (26.1) | 62 (27.9) | 0.041 |
Surgery history (%) | 137 (39.8) | 107 (37.0) | 0.058 | 85 (38.3) | 87 (39.2) | 0.018 |
LVEF (%) | 0.60 ± 0.11 | 0.59 ± 0.12 | 0.101 | 0.59 ± 0.12 | 0.59 ± 0.12 | 0.045 |
BMI (kg /m2) | 24.23 ± 3.07 | 24.25 ± 3.35 | 0.005 | 24.25 ± 3.06 | 24.16 ± 3.27 | 0.03 |
HGB (g/L) | 132.51 ± 16.44 | 126.32 ± 19.57 | 0.342 | 130.32 ± 16.44 | 129.14 ± 16.24 | 0.072 |
WBC (×109 /L) | 6.10 (5.00-7.30) | 6.70 (5.70-8.00) | 0.33 | 6.50 (5.33–7.90) | 6.40 (5.50–7.50) | 0.02 |
Neutrophil count (×109 /L) | 3.60 (2.80–4.70) | 4.30 (3.40–5.30) | 0.361 | 3.95 (3.00–5.00) | 4.00 (3.20-5.00) | 0.054 |
Lymphocyte count (×109 /L) | 1.60 (1.20–2.10) | 1.60 (1.20-2.00) | 0.052 | 1.70 (1.23–2.10) | 1.60 (1.20-2.00) | 0.082 |
Monocytes count (×109 /L) | 0.50 (0.40–0.60) | 0.60 (0.40–0.70) | 0.378 | 0.50 (0.40–0.60) | 0.50 (0.40–0.70) | 0.024 |
PLT count (×109 /L) | 184.00 (158.75–224.00) | 200.00 (165.00-236.00) | 0.174 | 188.00 (163.00-235.50) | 193.50 (164.00-234.00) | 0.023 |
PCT (%) | 0.17 (0.15–0.20) | 0.18 (0.15–0.21) | 0.124 | 0.18 (0.15–0.20) | 0.18 (0.15–0.21) | 0.044 |
PT (sec) | 11.56 ± 0.93 | 11.55 ± 1.35 | 0.007 | 11.53 ± 0.91 | 11.53 ± 1.29 | 0.007 |
APTT (sec) | 32.23 ± 4.12 | 33.08 ± 7.49 | 0.14 | 32.41 ± 4.42 | 32.68 ± 5.13 | 0.056 |
CPB (%) | 50 (14.5) | 42 (14.5) | < 0.001 | 29 (13.3) | 29 (13.3) | < 0.001 |
Surgery time (h) | 290.00 (255.00-330.00) | 299.00 (265.00-340.00) | 0.168 | 295.00 (257.25-332.75) | 298.50 (261.25-340.75) | 0.056 |
Number of anastomoses | 3.01 ± 0.81 | 3.13 ± 0.84 | 0.152 | 3.11 ± 0.75 | 3.10 ± 0.90 | 0.005 |
Arterial grafts | 263 (76.5) | 205 (70.9) | 0.126 | 160 (72.1) | 158 (71.2) | 0.02 |
LMWH(%) | 324 (94.2) | 280 (96.9) | 0.131 | 215 (96.8) | 214 (96.4) | 0.025 |
Aspirin (%) | 213 (61.9) | 181 (62.6) | 0.015 | 137 (61.7) | 137 (61.7) | < 0.001 |
Clopidogrel (%) | 165 (48.0) | 145 (50.2) | 0.044 | 114 (51.4) | 110 (49.5) | 0.036 |
ACEI (%) | 153 (44.5) | 143 (49.5) | 0.1 | 102 (45.9) | 100 (45.0) | 0.018 |
β-blocker (%) | 214 (62.2) | 218 (75.4) | 0.288 | 164 (73.9) | 157 (70.7) | 0.071 |