Table 3 Univariate and multivariate analysis of clinicopathological features in the development cohort

Age,mean(range)

58.15(25–88)

58.14(25–93)

0.938

Sex

Female

842(53.7%)

175(50%)

0.232

Male

726(46.3%)

175(50%)

Smoke

No

1118(71.3%)

243(69.43%)

0.527

Yes

450(28.7%)

107(30.57%)

Alcohol

No

1335(85.14%)

288(82.29%)

0.2090

Yes

233(14.86%)

62(17.71%)

Family cancer history

No

1216(77.55%)

280(80%)

0.353

Yes

352(22.45%)

70(20%)

Cancer history

No

1500(95.66%)

333(95.14%)

0.776

Yes

68(4.34%)

17(4.86%)

Tumor size

1.98(0.4-5)

2.72(0.5-5)

< 0.001*

< 0.001*

NTI

No

1545(98.53%)

327(93.43%)

< 0.001*

0.011*

Yes

23(1.47%)

23(6.57%)

PI

No

1136(72.45%)

192(54.86%)

< 0.001*

0.019*

Yes

432(27.55%)

158(45.14%)

LVI

No

1475(94.07%)

200(57.14%)

< 0.001*

< 0.001*

Yes

93(5.93%)

150(42.86%)

RUL

No

1013(64.6%)

257(73.43%)

0.002*

0.001*

Yes

555(35.4%)

93(26.57%)

RML

No

1465(93.43%)

318(90.86%)

0.113

Yes

103(6.57%)

32(9.14%)

RLL

No

1278(81.51%)

280(80%)

0.564

Yes

290(18.49%)

70(20%)

LUL

No

1181(75.32%)

250(71.43%)

0.149

Yes

387(24.68%)

100(28.57%)

LLL

No

1335(85.14%)

295(84.29%)

0.748

Yes

233(14.86%)

55(15.71%)

MD

No

388(24.74%)

205(58.57%)

< 0.001*

0.371

Yes

1180(75.26%)

145(41.43%)

LD

No

1278(81.51%)

146(41.71%)

< 0.001*

0.087

Yes

290(18.49%)

204(58.29%)

HD

No

1470(93.75%)

349(99.71%)

< 0.001*

NA

Yes

98(6.25%)

1(0.29%)

Acinus component

No

283(18.05%)

94(26.86%)

< 0.001*

0.400

Yes

1285(81.95%)

256(73.14%)

MP component

No

1360(86.73%)

231(66%)

< 0.001*

0.024*

Yes

208(13.27%)

119(34%)

Papillary component

No

1103(70.34%)

216(61.71%)

0.002*

0.261

Yes

465(29.66%)

134(38.29%)

Solid component

No

1430(91.2%)

234(66.86%)

< 0.001*

0.460

Yes

138(8.8%)

116(33.14%)

Lepidic component

No

1205(76.85%)

338(96.57%)

< 0.001*

< 0.001*

Yes

363(23.15%)

12(3.43%)

Mucous component

No

1515(96.62%)

325(92.86%)

0.002*

0.181

Yes

53(3.38%)

25(7.14%)

Papillary predominant

No

1326(84.57%)

292(83.43%)

0.654

Yes

242(15.43%)

58(16.57%)

Solid predominant

No

1504(95.92%)

288(82.29%)

< 0.001*

0.246

Yes

64(4.08%)

62(17.71%)

Lepidic predominant

No

1399(89.22%)

348(99.43%)

< 0.001*

0.688

Yes

169(10.78%)

2(0.57%)

MP predominant

No

1556(99.23%)

322(92%)

< 0.001*

0.001*

Yes

12(0.77%)

28(8%)

Mucous predominant

No

1561(99.55%)

345(98.57%)

0.083

Yes

7(0.45%)

5(1.43%)

Acinus predominant

No

494(31.51%)

155(44.29%)

< 0.001*

0.271