Table 3 Univariable and multivariable Cox regression of stage T1-T3N0M0 ESCC patients in the Sun Yat-sen University Cancer Center
Covariate | Univariable Cox regression | Multivariable Cox regression | ||
|---|---|---|---|---|
P value | HR (95% CI) | P value | HR (95% CI) | |
Sex | ||||
Female | 1 (reference) | 1 (reference) | ||
Male | 0.899 | 1.016 (0.799–1.292) | 0.197 | 1.177 (0.919–1.507) |
Age (continuous) | 0.008 | 1.016 (1.004–1.028) | 0.972 | 1.000 (0.987–1.013) |
Smoking history | ||||
No | 1 (reference) | |||
Yes | 0.084 | 1.220 (0.973–1.529) | ||
pT stage | 0.012 | 0.001 | ||
T1 | 1 (reference) | 1 (reference) | ||
T2 | 0.05 | 1.457 (0.999–2.125) | 0.04 | 1.490 (1.019–2.177) |
T3 | 0.003 | 1.692 (1.191–2.405) | < 0.001 | 1.935 (1.354–2.766) |
Tumor differentiation | 0.006 | < 0.001 | ||
Grade I | 1 (reference) | 1 (reference) | ||
Grade II | 0.947 | 1.009 (0.776–1.312) | 0.413 | 1.117 (0.857–1.457) |
Grade III | 0.007 | 1.479 (1.111–1.969) | < 0.001 | 1.763 (1.314–2.366) |
Esorisk class | < 0.001 | < 0.001 | ||
Class A | 1 (reference) | 1 (reference) | ||
Class B | 0.010 | 1.477 (1.100–1.984) | 0.007 | 1.544 (1.129–2.111) |
Class C | < 0.001 | 2.316 (1.762–3.044) | < 0.001 | 2.416 (1.748–3.339) |
Surgical approach | 0.001 | 0.014 | ||
Sweet | 1 (reference) | 1 (reference) | ||
Ivor-Lewis | 0.041 | 1.793 (1.025–3.138) | 0.014 | 2.152 (1.68–3.964) |
McKeown | 0.027 | 0.727 (0.548–0.965) | NA | NA |
Other | 0.014 | 1.615 (1.103–2.366) | NA | NA |
Transthoracic laterality | 0.007 | 0.121 | ||
Left | 1 (reference) | 1 (reference) | ||
Right | 0.120 | 0.812 (0.625–1.056) | 0.802 | 0.962 (0.714–1.298) |
Other | 0.014 | 1.613 (1.101–2.363) | 0.046 | 1.485 (1.007–2.191) |